Objective In the adult neurogenic niches, neural stem cells (NSCs) generate neurons throughout life. During aging, the number of newborn neurons is clearly reduced, although it is still very debated what specifically happens to the NSCs: do they die, increase their quiescence or change their fate? It is emerging that NSCs are heterogeneous, with different subtypes, in particular quiescent and active NSCs, responding differently to neurogenic stimuli, including aging. However, due to difficulties in distinguishing NSCs subtypes in vivo, their behavior in the physiological environment, their molecular hallmarks, and especially how those are changed during aging are still elusive. These are key questions in neuroscience and stem cell biology. Thanks to the combination of the host laboratory expertise with mine, the current action proposes to develop a strategy to discriminate different NSCs in vivo and shed new light on their behavior, molecular properties and the changes occurring during life. The expected results are going to provide critical information on the regenerative potential of NSCs subtypes and on whether and how the aging phenotype can be reverted, with a consequent strong scientific and social impact. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencescell biologymedical and health sciencesmedical biotechnologycells technologiesstem cells Keywords NSCaging Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Call for proposal H2020-MSCA-IF-2014 See other projects for this call Funding Scheme MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinator KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW Net EU contribution € 165 598,80 Address KLOVENIERSBURGWAL 29 HET TRIPPENHUIS 1011 JV AMSTERDAM Netherlands See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 165 598,80
