Objective
Traumatic Brain Injury (TBI) is the leading cause of death and disability in young adults. Hours or days after the primary injury, secondary injury will develop. This secondary injury is responsible for most in-hospital deaths after TBI. Early interventions to prevent secondary injury are currently targeted at reducing intracerebral pressure and promoting cerebral blood flow (CBF), aiming to improve brain oxygenation and reduce ischaemia. However, there is increasing evidence that other mechanisms besides ischaemia are important in the development of secondary damage. Because our brain depends on glucose for functioning, alterations in cerebral glucose metabolism provide insight into the causes of secondary brain damage. The influence of plasma glucose has been studied, but the relation between body and brain glucose metabolism after TBI is unclear. In addition, there are indications that local neuroinflammation influences local glucose metabolism. New techniques, such as positron emission tomography (PET) with 18-Fluorodeoxyglucose (18FDG) and cerebral microdialsyis, allow detailed study of brain metabolism after TBI. During this project we aim to study the causes and consequences of alterations in brain glucose metabolism using 18FDG PET and microdialysis. We will study the influence of alterations in oxygen supply, neuroinflammation and body glucose on alterations in glucose metabolism. Thereafter, the consequences of alterations in glucose metabolism on brain tissue will be studied, using structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). This will provide novel insights into the underlying mechanisms of secondary injury following TBI and its long term consequences. These data should provide a basis for the design and assessment of future neuroprotective therapies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
- medical and health sciences basic medicine neurology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.