Cel This project will take direct action in exploiting the powerful planarian model system to achieve novel insights into the molecular processes underpinning oncogenesis and cancer. Based on the principle that biochemical and physiological functions of many genes are conserved across phyla we will identify planarian genes that control the migration, proliferation and differentiation of the highly proliferative pluripotent adult stem cells (pASCs). We will combine a bespoke specially designed partial irradiation assay, bioinformatic and expression based candidate gene identification and the capacity to perform RNAi based screens of gene function to identify novel genes controlling pASCs that are conserved in humans. Those novel genes of greatest promise will then be studied in mammalian cancer cell lines using the insight gleaned from planarians. This project brings together, for the first time, a world-class planarian laboratory with an eminent cancer cell biologist, Dr Kosaka, who will acquire all the expertise required to exploit the planarian system and at the same time transfer his extensive knowledge of cancer biology to the Aboobaker laboratory. Dziedzina nauki natural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencescell biologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncology Słowa kluczowe Evolution multicellular organisms origin of cancer cancer initiation high-throughput screening over-proliferation Program(-y) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Temat(-y) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Zaproszenie do składania wniosków H2020-MSCA-IF-2014 Zobacz inne projekty w ramach tego zaproszenia System finansowania MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Koordynator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Wkład UE netto € 195 454,80 Adres WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford Zjednoczone Królestwo Zobacz na mapie Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 195 454,80