Cel The main goal of this IF research proposal is to produce novel nanoparticle-based multimodal contrast agents for their use in breast cancer diagnosis by combining Magnetic Resonance Imaging, Digital Mammography, X-ray Computed Tomography and Ultrasonography. In doing so, we will develop a new high-productivity strategy to synthesize multimodal hybrid nanoparticles, which consists in femtosecond-laser-induced-ablation of a metal plate immersed into a solvent containing chemicals, in combination with direct nanosecond-laser photolysis in solution of these chemicals. This research will be coupled to an in situ study of the high-productivity laser fabrication process and the analysis of the underlying mechanisms which allows the nucleation and growth of these hybrid nanoparticles. Moreover, we will analyze the structure, composition, physical and colloidal properties of the as-synthesized hybrid nanoparticles, as well as the in vitro performance of these nanoparticles as contrast agents in Magnetic Resonance Imaging, Ultrasonography and X-ray imaging techniques. We will also evaluate the citotoxicity of the as synthesized hybrid nanoparticles in normal cells and tumor breast cells lines. Finally, we will target these nanoparticles toward the human epidermal growth factor receptor 2 (HER2) which is overexpressed in breast cancers with a poor prognosis and higher disease recurrence, and we will evaluated in vitro the targeting ability of the obtained anti-HER2-nanoparticles conjugates for HER2+ breast cancer cells. Dziedzina nauki medical and health sciencesclinical medicineoncologybreast cancerengineering and technologymaterials engineeringcoating and filmsengineering and technologynanotechnologynano-materialsengineering and technologymaterials engineeringceramicsnatural sciencesphysical sciencesopticslaser physics Słowa kluczowe ultra-short pulse laser ablation in liquids laser solution photolysis synthesis of multimodal nanoparticles colloidal dispersions MRI Ultrasonography Digital Mammography X-ray CT Program(-y) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Temat(-y) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Zaproszenie do składania wniosków H2020-MSCA-IF-2014 Zobacz inne projekty w ramach tego zaproszenia System finansowania MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Koordynator UNIVERSITAT WIEN Wkład UE netto € 166 156,80 Adres UNIVERSITATSRING 1 1010 Wien Austria Zobacz na mapie Region Ostösterreich Wien Wien Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 166 156,80