MULTICELLProject ID: 657096
Finanziato nell'ambito di:
Division of labour and the origin of multicellularity
Dettagli del progetto
Costo totale:EUR 171 460,80
Contributo UE:EUR 171 460,80
Invito a presentare proposte:H2020-MSCA-IF-2014See other projects for this call
Meccanismo di finanziamento:MSCA-IF-EF-RI - RI – Reintegration panel
Understanding the evolution of multicellularity and cellular differentiation/ complexity is one of the greatest challenges in biology. Of particular interest is to determine the evolutionary processes (selective causes) and mechanisms underlying the evolutionary transition from single cells to multicellular organisms.
This project will use cyanobacteria as a model system to determine whether cellular differentiation is a cause or consequence of multicellularity. A novel theory will be tested, which predicts that the division of labour/ differentiation among cells drives the transition to a multicellular state. This will be contrasted with the classical view, where cellular specialization originates only at a much later state during the transition. The proposed project will adopt an interdisciplinary approach by combining experimental evolution (WP1) with phylogenomics (WP2). More specifically, populations of unicellular cyanobacteria will be subjected to long-term experimental evolution under two different regimes that favour either the specialization of cells into performing different physiologically incompatible processes, or the formation of non-differentiated aggregates (WP1). By linking the phenotype to the underlying genotype and to gene expression patterns, the critical steps for the transition to multicellularity will be established at the genome level. This evolutionary sequence will be directly compared to the one inferred from the cyanobacterial phylogeny (WP2). Here, whole genomes will be used to reconstruct the gain and loss events for the main ‘multicellular traits’, such as filament formation and cellular differentiation.
The findings will not only provide insight into the key events during the transition to multicellularity but will also be the first study that directly relates a transition that was achieved under artificial conditions in the laboratory to one that actually happened more than 3 billion years ago in this phylum.
Contributo UE: EUR 171 460,80