Skip to main content
European Commission logo print header

Evolutionary and developmental origin of the nervous system

Ziel

Little is known about the genetic and developmental mechanisms that led to the evolution of the nervous system in the ancestors of eumetazoans. We plan to address the issue by studying a basal metazoan - the cnidarian Nematostella vectensis. The cnidarians are a sister group to bilaterians and possess a surprising complexity of genetic network, yet a relatively simple overall morphology including a diffuse nervous system. By studying the neural progenitors, we aim to address the problem from a developmental point of view. We propose to employ the state-of-the-art technology (transcriptome sequencing, in vivo imaging, transgenesis) in order to gain insight into the molecular characteristics of neural progenitors of Nematostella and to understand how the different populations of neural progenitors relate to neuronal diversity present in Nematostella. We will also analyse the function of a neural progenitor marker SoxB2, among others, in order to determine the role in the genetic hierarchy of the formation of the first nervous systems. Last, we will perform a comparative analysis of Nematostella neural progenitor make up with other cnidarians and bilaterians. This will elucidate the common and distinct features of cnidarian and bilateral nervous systems, which in turn will enable us to reconstruct the common ancestor.

Koordinator

UNIVERSITAT WIEN
Netto-EU-Beitrag
€ 178 156,80
Adresse
UNIVERSITATSRING 1
1010 Wien
Österreich

Auf der Karte ansehen

Region
Ostösterreich Wien Wien
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
€ 178 156,80