Objective
The development of gold nanostructures is a topic of high interest due to their extensive use in biomedical applications, biosensing and bioimaging because of their specific properties: high stability, ease of detection, facile synthesis and functionalization, etc. It would be of potential interest to predict the photobehaviour of AuNPs before introducing them in a biological environment. In this respect, when NPs interact in a living milieu, proteins will adsorb onto its surface generating a protein corona; this may provoke changes in the biological function of the protein and in the photophysical properties of the AuNP; thus, the photophysical behaviour of AuNPs in solution cannot be directly extrapolated to the biological media. These effects have been barely investigated up to now. The design of new gold nanoparticles whose photophysical behaviour can be extrapolated in a greater degree to a biological environment is of potential interest for in vivo applications due to the fact that their photobehaviour would be predictable within cells. Functionalization of AuNPs with nonsteroidal anti-inflammatory 2-arylpropionic drugs is proposed. These drugs are widely prescribed and are able to generate cytotoxic singlet oxygen, which induces cell tumour death. Their photophysical properties have been well characterised in solution. However, to the best of our knowledge, functionalization of AuNPs with drugs of this family has never been performed. The photophysical properties of the new nanomaterials will be studied in different microenvironments that tend to mimic cellular milieus, such as micellar or microemulsion media. Investigation of their photobehaviour in the presence of proteins is also planned. Finally, studies in an intracellular environment and in vivo will also be performed in order to check the potential application of the new conjugates as biosensors or photodynamic therapy agents.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences chemical sciences organic chemistry alcohols
- engineering and technology nanotechnology nano-materials
- natural sciences physical sciences optics laser physics
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
NR4 7TJ NORWICH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.