Objetivo In neuronal networks of the brain, synapses are the connection points between neurons. The dynamics (or plasticity) of these synapses allow us to think, learn and memorize. A deeper understanding of these phenomena requires investigations of single synapses. Synapses have been intensively studied in vivo but in such studies the physiological complexity limits the investigations at the single synapses level. Despite tremendous technical and conceptual advances of in vivo studies, we miss (1) a better understanding of the mechanics of synapses formation; (2) observing directly the chemical activity at single synapses; (3) investigating the role of neuronal network topology in synaptic plasticity. These classical limitations can now be overcome by alternative in vitro approaches, using recent technological advances in microfluidics and nano-technologies. The aim of NANOSYNNETS is to use vertical arrays of NANOwires (aNWs) to study in vitro the formation and plasticity of single SYnapses in Neuronal NETworkS with controlled topologies. With my expertise in growing controlled neuronal networks in microfluidic chips, I decided to join the one of the leading group in bio-nanotechnologies, lead by Karen Martinez (KM) and based at the NanoScience Center (NSC) of the University of Copenhagen (UCPH), to exploit novel technologies for the investigation of in vitro single synapse formation, activity and plasticity. This novel approach will give a complementary and cutting-edge point of view to classical in vivo studies of synapses and will thereby provide unmatched insights into neurobiology and will shed new lights on unanswered questions in learning mechanisms or neuronal communication. Ámbito científico natural sciencesbiological sciencesneurobiologynatural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsnatural sciencesmathematicspure mathematicstopologyengineering and technologynanotechnologyengineering and technologyelectrical engineering, electronic engineering, information engineeringinformation engineeringtelecommunicationstelecommunications networks Palabras clave nanowires synapses neuronal networks synaptic plasticity Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Convocatoria de propuestas H2020-MSCA-IF-2014 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinador KOBENHAVNS UNIVERSITET Aportación neta de la UEn € 212 194,80 Dirección NORREGADE 10 1165 Kobenhavn Dinamarca Ver en el mapa Región Danmark Hovedstaden Byen København Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 212 194,80