Objective
Pyrrolizidine alkaloids are more than 600 individual compounds that are hazardous for animals and humans if ingested. The 3% of the flowering plants produce these type of molecules and grow as weeds in agricultural production systems throughout the world where they can contaminate commonly consumed foods (eg. grain, milk, meat, eggs, honey, pollen). Chronic exposure to low concentrations of these alkaloids can be the cause of progressive, chronic disease (hepatic damage, vascular obstructive disease, and cancer) that may be difficult to attribute to their presence in food. The 2007 statement from the European Food Safety Authority calls to generate more quantitative data sets on pyrrolizidine alkaloids levels in milk and honey, and to determine which PA plants and/or marker PA need to be considered relevant in animal feed. In the same direction, this Authority pointed in 2011 that toxicological data for pyrrolizidine alkaloids commonly found in honey was needed. Even though some countries have regulated the concentration of pyrrolizidine alkaloids in herbs used in traditional medicines, a general European legislation regulating the concentrations of these alkaloids in food is still pending. The present project propose the use of state of the art technology (UPLC-Qtof-MS, antibody microarrays) to better understand the distribution of pyrrolizidine alkaloids producing plants in relation to food content, and determine the incidence of exposure to these molecules in humans and animals. The results will impact several levels of society, the scientific results will provide science legal advisors with solid data to better inform law makers in the regulation of pyrrolizidine alkaloids in food, society will gain knowledge on the exposure to this type of molecules and on hazardous dietary habits, and food industry will benefit through the introduction of practices to avoid pyrrolizidine alkaloids containing components in food.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine integrative and complementary medicine
- agricultural sciences agriculture, forestry, and fisheries agriculture grains and oilseeds
- engineering and technology other engineering and technologies food technology food safety
- medical and health sciences clinical medicine oncology
- agricultural sciences animal and dairy science domestic animals animal husbandry animal feed
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
BT7 1NN BELFAST
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.