Objective
Transposable elements (TEs) are DNA sequences that are able to spread within and between genomes. While transposition may lead to evident harmful effects, TEs can also positively impact the host genome by, for instance, donating intrinsic regulatory elements such as promoters. The main goal of this research project is to understand the regulatory changes that TEs engage within host genomes. While in mammals TE-derived promoters are often observed, only recently Drosophila TEs were described as potential platforms of gene regulatory networks, opening a new field for important discoveries. Since TEs are extremely active in fruit flies and Drosophila is found worldwide, TE copies that are population-specific are observed. Drosophila constitutes therefore a perfect model to study the impact of TEs in the host transcriptome. We hypothesize that Drosophila TEs are able to act as gene promoters and cause differential gene expression between wild-derived strains. Our first aim is to discover strain-specific TE-derived promoters involved in differential gene expression between Drosophila melanogaster populations by using a genome-wide high throughput sequencing method named RAMPAGE. In our second aim we will determine how histone modifications regulate TE-derived promoters by producing chromatin maps for each strain studied. The comparison of full sites (sites containing the insertion of a TE in one population) with empty sites (sites devoid of a TE insertion in another population) allow us to clearly demonstrate the impact and regulation of TE promoters.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences zoology mammalogy
- medical and health sciences clinical medicine embryology
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
69622 Villeurbanne Cedex
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.