Objective
Iron-sulfur [Fe-S] clusters play a vital role in numerous cellular functions. They are a sine qua non for cellular energy production and maintenance of genomic stability. Therefore, elucidation of the biogenesis of [2Fe-2S] and [4Fe-4S] proteins is of utmost importance for basic science in its broadest sense, as it is for ongoing efforts to establish their relevance to human disease and their utilization for biotechnological production of fine chemicals in microorganisms. The iron-sulfur cluster (ISC) assembly process is responsible for incorporating the inorganic cluster into [Fe-S]-associated proteins in the mitochondria. Cytosolic and nuclear [Fe-S] protein assembly that dictates cellular iron concentrations and DNA integrity outside of the mitochondria also depends on the function of the ISC machinery. The mitochondrial ISC biogenesis machinery entails at least 17 proteins, yet how the proteins for [4Fe-4S] maturation work in a unified manner to produce the active cluster and transfer it to target proteins remains poorly understood. FourFeFourS intends to discover the underlying mechanisms of [4Fe-4S] biogenesis in the mitochondria, which could shed new light into how dysfunction of the proteins involved may lead to fatal diseases. To this end, studies will combine a biochemical reconstitution assay of the biological process utilizing isolated ISC proteins in conjunction with spectroscopic and spectrometric experiments that elucidate detailed protein function and molecular structure. In carrying out this cutting-edge research under the tutelage of a world-leading expert on iron-sulfur protein biogenesis, I will expand my expertise within the multidisciplinary field of biochemistry – in particular my understanding of the roles of metal ions in biology. In the process, I will build a solid foundation for a future research career as a group leader within the European Union.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences genetics DNA
- natural sciences chemical sciences electrochemistry electrolysis
- natural sciences biological sciences microbiology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
35037 Marburg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.