Objective
Non-alcoholic fatty liver disease (NAFLD) is a rapidly growing clinical problem, affecting a third of the European population. The transition of hepatic fat accumulation to inflammation is the key event taking place in the progression of NAFLD. This is controlled by a number of inflammatory and immune pathways including the activity of Natural Killer (NK) and Natural Killer T (NKT) cells. Progression from hepatic lipid deposition to inflammation and cirrhosis also follows a substantially variable course. It has been estimated that less than 10% of patients develop end-stage liver disease. Individual variability for disease progression is partly controlled by environmental factors and genetic background. However, it is not known how immune and inflammatory pathways are orchestrated by epigenetic mechanisms. The project hypothesises that “NK and NKT cells are programmed into inflammatory state by epigenetic modifications in progression from fatty liver to inflammation”. In this project, histone modifications and DNA methylation will be studied by genome-wide and loci-specific approaches in NK and NKT cells purified from animal models of NAFLD and a prospectively-designed human NAFLD cohort. Reversibility of these modifications will be investigated following the regression of liver disease in animal models and after the implementation of lifestyle changes in humans. Lastly, the therapeutic potential of targeting histone modifying enzymes by short hairpin RNA and small molecule inhibitors in NK and NKT cells for modulating inflammatory response will be investigated. The project will be the first comprehensive study investigating cross-talking epigenetic mechanisms in NK and NKT cells in NAFLD.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences health sciences public health
- medical and health sciences health sciences infectious diseases
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine hepatology
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
34450 Istanbul
Türkiye
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.