Objectif Schmallenberg virus (SV) is a pathogen that has been discovered in European livestock 3 years ago. Since then, it has been found that this virus is associated with disease in sheep, goats and cattle across Europe . In livestock, the symptoms associated with the disease include stillbirths and malformations in newborn animals. The presence of the virus in Spain, France, Germany, Italy, the UK, the Netherlands as well as Russia, has shown that this disease is a fast spreading threat to the European livestock industry, and has the potential to cause significant economic impact across the continent. Furthermore, due to high volumes in international trade of livestock, the potential of this disease to spread beyond Europe poses another potential threat to the industry. Recent work using a related bunyavirus (Rift Valley Fever virus) has found that effective DNA vaccines can be generated . These vaccines have the advantage of being administered easily, having low-manufacturing costs, and providing long-lasting efficacy-making it ideal for large-scale vaccination campaigns. Furthermore, studies on related viruses have shown that monoclonal antibodies can be generated for use in diagnostic testing. Using these concepts, we propose to extend this principle to Schmallenberg virus, in order to: i) develop an easy-to-use diagnostic test for Schmallenberg detection; and ii) develop a DNA vaccination strategy that could be used to limit further future outbreaks. Champ scientifique natural sciencesbiological sciencesmicrobiologyvirologynatural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesagricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandry Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Thème(s) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Appel à propositions H2020-MSCA-IF-2014 Voir d’autres projets de cet appel Régime de financement MSCA-IF-EF-ST - Standard EF Coordinateur ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS Contribution nette de l'UE € 158 121,60 Adresse PARQUE TECNOLOGICO EDIFICIO 801 A 48160 Derio Vizcaya Espagne Voir sur la carte Région Noreste País Vasco Bizkaia Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 158 121,60
