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Cholesterol metabolism as a driver of prostate cancer aggressiveness

Objective

According to the WHO, prostate cancer (PCa) is the most common cancer in men in the European Union (EU). The current
view of cellular transformation and cancer progression supports the notion that cancer cells must undergo a metabolic
reprogramming in order to survive in a hostile environment. Tumors are not homogeneous entities, and most cancers retain
a differential fraction of cells with increased self-renewal capability (cancer stem or initiating cells), that accounts for
recurrence and resistance to therapy. While we know more about the metabolism of tumor cells and its implication in cancer,
our knowledge about the metabolism of cancer-initiating cells remains insufficient.
Obesity is associated with increased risk of prostate cancer metastasis and death. On other side, statins treatment reduces
the risk of PCa, indicating that cholesterol might have a role in the onset of the disease. Overweight and obesity rates in EU
affect 50 and 20% of the population respectively. Therefore, it is critical to define the role of environmental factors such as
nutrition and “lifestyle” for cancer prevention.
Preliminary studies in our lab indicate that cancer initiating cells are highly enriched in cholesterol synthesis genes and their
sphere formation capacity is dependent on cholesterol synthesis. We hypothesize that an active cholesterol metabolism is
essential for prostate cancer-initiating cell function, and that the use of cholesterol synthesis inhibitors might target this subpopulation of aggressive cancer cells.
I will use a combined transcriptomic and metabolomic approach to define the alterations of cholesterol metabolism. I will
study the mechanisms by which cholesterol metabolism regulates CIC function. I will study the feasibility of therapeutic
targeting of cholesterol metabolism in prostate cancer using a well established mouse model. And finally, I will do a
prospective associative study of statin treatment with CICs markers expression in patients.

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MSCA-IF-EF-RI - RI – Reintegration panel

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Call for proposal

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(opens in new window) H2020-MSCA-IF-2014

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Coordinator

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 158 121,60
Address
PARQUE TECNOLOGICO EDIFICIO 801 A
48160 DERIO VIZCAYA
Spain

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Region
Noreste País Vasco Gipuzkoa
Activity type
Research Organisations
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 158 121,60
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