Objetivo Powdery mildew caused by the fungus Blumeria graminis f.sp. tritici (Bgt) is a devastating disease of wheat with poorly understood plant-pathogen interactions. Sequencing of the Bgt genome indicated that hundreds of effector proteins are manipulating the plant cell and determining the virulence spectrum of a particular mildew strain. Bgt rapidly adapted to the introduction of the new host species bread wheat, which arose only 8,000-10,000 years ago. Bgt has since evolved into strains which are specialized on domesticated wheat and such which grow on wild wheat species. Genes responsible for the host specificity in an obliagte biotrophic fungus are unknown. To study the mechanisms of adaptive evolution in the highly repetitive Bgt genome, whole genome re-sequencing data of a mapping population derived from a cross between Bgt isolates that differ in their host specialization will be used to determine the frequency and distribution of recombination events and precise mapping of recombination breakpoints. Of particular interest is to study the impact of recombination on the clusters of effector genes. The factors that determine host specificity will be genetically mapped. This will allow conclusions on which and how many genes were responsible for the Bgt adaptation to the bread wheat host. The proposed research is taking a multi-disciplinary approach combining whole genome re-sequencing, classical genetics, molecular plant pathology and comparative genomics. This study will broaden our understanding of Bgt genome evolution and will help to design rational strategies for sustainable powdery mildew disease management. Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesmicrobiologymycologymedical and health sciencesbasic medicinepathologynatural sciencesbiological sciencesgeneticsgenomes Palabras clave Blumeria graminis tritici wheat recombination effector gene host specialization plant-pathogen interactions adaptive evolution powdery mildew Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2014-GF - Marie Skłodowska-Curie Individual Fellowships (IF-GF) Convocatoria de propuestas H2020-MSCA-IF-2014 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinador UNIVERSITY OF HAIFA Aportación neta de la UEn € 260 674,20 Dirección ABBA KHUSHY BLVD MOUNT CARMEL 31905 Haifa Israel Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 260 674,20 Socios (1) Ordenar alfabéticamente Ordenar por aportación neta de la UE Ampliar todo Contraer todo Socio Las organizaciones asociadas contribuyen a la aplicación de la acción, pero no firman el acuerdo de subvención. UNIVERSITAT ZURICH Suiza Aportación neta de la UEn € 0,00 Dirección RAMISTRASSE 71 8006 Zurich Ver en el mapa Región Schweiz/Suisse/Svizzera Zürich Zürich Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 175 419,60