Cel A spinal cord injury (SCI) has consistent social costs, due to dramatic and disabling consequences and a high incidence on the youngest and most productive population, which can hardly be alleviated by the very few and controversial therapeutic treatments. In a recent case report, epidural electrostimulation combined with an intense training enabled some highly variable conscious motor control of legs in four motor complete spinal cord injured volunteers. The aim of understanding the mechanisms behind these improvements can help define more effective pharmacological and electrical stimulating protocols with breakthrough technology to restore functions after a SCI. Experiments will be performed on adult rats, with an experimental SCI closer to human chronic lesions, on which I will apply the novel enabling protocol with epidural electrostimulation associated with an intense motor training. Outcome will be evaluated with innovative combinations of electromyographic and kinematic assessments of locomotion and standing posture, in vivo terminal intracellular recordings from lumbar motoneurons and histological examination of spared axons across the lesion. Then, I will employ carbon nanotubes to devise nanostructured innovative stimulation arrays for a more specific and focussed epidural stimulation to enhance recovery. The unique experience of Prof. Edgerton and Prof. Ballerini will allow me to acquire new skills on both preclinical SCI models and assessments and nanotechnologies, to increase my international collaborations, support my research through greater funds and a new in vivo research line, with the aims of obtaining a professorship and a greater visibility in the field. The project is deemed to advance and diffuse scientific knowledge and further sustain European competitiveness, through two patents on discoveries with a great commercial impact and possible clinical applications to reduce healthcare expenses. Dziedzina nauki natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicinephysiologypathophysiologyengineering and technologynanotechnologysocial scienceseconomics and businesseconomicsproduction economicsproductivityengineering and technologymaterials engineeringcoating and films Program(-y) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Temat(-y) MSCA-IF-2014-GF - Marie Skłodowska-Curie Individual Fellowships (IF-GF) Zaproszenie do składania wniosków H2020-MSCA-IF-2014 Zobacz inne projekty w ramach tego zaproszenia System finansowania MSCA-IF-GF - Global Fellowships Koordynator SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE Wkład UE netto € 262 269,00 Adres VIA BONOMEA 265 34136 Trieste Włochy Zobacz na mapie Region Nord-Est Friuli-Venezia Giulia Trieste Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 262 269,00 Partnerzy (1) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko Partner Organizacje partnerskie biorą udział w realizacji działania, jednak nie podpisują umowy o grant. THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Stany Zjednoczone Wkład UE netto € 0,00 Adres FRANKLIN STREET 1111 12 FLOOR 94607 OAKLAND CA Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 172 130,40