Objectif "Cardiovascular diseases are the leading causes of mortality in Europe and worldwide. Currently, synthetic prostheses used in bypass vascular surgery are produced from polyethylene terephthalate [PET] and expanded polytetrafluoroethylene [ePTFE]. Those materials show less than optimal, insufficient biocompatibility and durability properties, especially if used for SMALL DIAMETER BLOOD VESSELS. Within the frame of ERC Advanced Grant “BIOSILICA” (From gene to biomineral: Biosynthesis and application of sponge biosilica; Grant No. 268476), we unexpectedly discovered that distinct natural, biodegradable and biofunctional polymers, including biosilica and inorganic polyphosphate (anionic), are not only bio-printable but also morphogenetically active. Likewise attractive is that those biopolymers can be functionally processed by non-toxic and charged (cationic) linkers with growth/differentiation potencies. Therefore, these formulations, backbone polymers and bioactive linkers, allowed the fabrication of unprecedented “Modular Small Diameter Vascular Grafts (MSDVGs)"" which combine in an optimal way physical strength with physiological activity. Furthermore, the fabrication of the synthetic vessels is performed by a home-made, easy to handle, extruder device which has been developed by our group. Therefore, this new ERC-PoC project will provide small diameter (< 6 mm) blood vessel implants (incl. the fabrication device - the extruder) urgently required in clinics, with superior properties and at low-costs, at the end of the project. We are definitively convinced that, in view of their advantages, our vessels will be preferentially used for patients requiring bypass surgery. The experimental data gathered disclose that we have in hand a product with a clear biomedical application potential. Besides of their economical value, our new type of artificial blood vessel will certainly improve the quality of life and well-being of patients with cardiovascular disorders." Champ scientifique social sciencessociologydemographymortalitymedical and health sciencesclinical medicinesurgerysurgical specialtiesnatural scienceschemical sciencespolymer sciencesmedical and health sciencesclinical medicinecardiologycardiovascular diseasesmedical and health sciencesmedical biotechnologyimplants Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Thème(s) ERC-PoC-2014 - ERC Proof of Concept Grant Appel à propositions ERC-2014-PoC Voir d’autres projets de cet appel Régime de financement ERC-POC - Proof of Concept Grant Institution d’accueil UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ Contribution nette de l'UE € 149 962,00 Adresse Langenbeckstrasse 1 55131 Mainz Allemagne Voir sur la carte Région Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 149 962,00 Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ Allemagne Contribution nette de l'UE € 149 962,00 Adresse Langenbeckstrasse 1 55131 Mainz Voir sur la carte Région Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 149 962,00