Genetic Mapping of Evolutionary Developmental Variation using Hybrid Mouse in vitro Crosses

Projektinformationen

HybridMiX

ID Finanzhilfevereinbarung: 639096

DOI 10.3030/639096

Abgeschlossenes Projekt

EK-Unterschriftsdatum 18 Mai 2015

Startdatum 1 August 2015

Enddatum 31 Juli 2020

Finanziert unter

• EXCELLENT SCIENCE - European Research Council (ERC)

Gesamtkosten € 1 499 923,00

EU-Beitrag € 1 499 923,00

Koordiniert durch

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

Ziel

Discovering the genetic changes underlying species differences is a central goal in evolutionary genetics. Most evolutionarily important traits affecting fitness are complex or quantitative traits, whose genetic bases are elusive. In mammals, dissecting the genetic basis of complex trait variation is particularly challenging, because efficient genetic mapping requires enormous pedigrees or specialized genetic panels that are typically beyond the resources of individual groups. Using a radically novel method to circumvent breeding limitations by “breeding” mice in vitro, I propose to dissect the genetic basis of evolutionary developmental variation. This ground-breaking approach will allow me to create large genetic mapping panels of potentially any size from mouse interspecific hybrids of increasing evolutionary divergence. In vitro crosses promise a breakthrough in evolutionary biology: by bypassing hybrid sterility and inviability, we will ask which genetic changes underlie species differences. The proposed experiments address how genetic changes accumulate during evolution of new species to shape gene regulatory networks and cause phenotypic changes at the gene expression, fitness and organismal level. This research has the potential to revolutionize genetic mapping. If realized, its impact on personalized medicine, agricultural science and evolutionary research cannot be understated.

Wissenschaftliches Gebiet

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• natural sciences › biological sciences › evolutionary biology
• medical and health sciences › health sciences › personalized medicine
• natural sciences › biological sciences › zoology › mammalogy
• natural sciences › biological sciences › genetics › genomes

Programm/Programme

• H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme

Thema/Themen

• ERC-StG-2014 - ERC Starting Grant

Aufforderung zur Vorschlagseinreichung

ERC-2014-STG

Finanzierungsplan

ERC-STG - Starting Grant

Gastgebende Einrichtung

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

• Netto-EU-Beitrag: € 1 499 923,00
• Adresse: HOFGARTENSTRASSE 8 ; 80539 Munchen ; Deutschland
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Aktivitätstyp: Research Organisations
• Gesamtkosten: € 1 499 923,00

Begünstigte (1)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Deutschland

• Netto-EU-Beitrag: € 1 499 923,00
• Adresse: HOFGARTENSTRASSE 8 ; 80539 Munchen
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Aktivitätstyp: Research Organisations
• Gesamtkosten: € 1 499 923,00