Objectif According to the World Health Organization, infertility is a medical condition that affects up to 14% of couples under reproductive age. The increase in infertility has led to the exponential rise in the use of assisted reproduction as a route for conceiving a baby, currently representing 1.5% of children born in Europe. Although multiple factors may contribute to infertility, the limited availability of human gametes for its study restricts the capacity of researchers in establishing the causes of this decline. To address this limitation, a talented Fellow with background in physiology of reproduction will join a leading laboratory in developmental biology to conduct multidisciplinary research aimed at developing a platform for the generation of human gametes in the laboratory. A combination of state-of-the-art tools in genomics and cell biology will be used to gain new understanding of how gamete precursors form in vivo, and this knowledge will be used to develop culture systems to generate gametes in vitro. These approaches will equip the Fellow with comprehensive new skills essential for fulfilling these objectives. The transfer of knowledge builds on the host’s expertise in animal biotechnology, the provision of interdisciplinary training in human stem cell differentiation by collaborators, and on the Fellow’s knowledge of reproductive biology. The output of the project will address key societal challenges for the EU in the areas of Health, demographic change and well-being and will contribute to the expansion of the network of experts in biotechnology. Champ scientifique medical and health sciencesmedical biotechnologygenetic engineeringgene therapymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineobstetricsmedical and health sciencesbasic medicinephysiologymedical and health sciencesclinical medicineembryology Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Thème(s) MSCA-IF-2014-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Appel à propositions H2020-MSCA-IF-2014 Voir d’autres projets de cet appel Régime de financement MSCA-IF-EF-ST - Standard EF Coordinateur THE UNIVERSITY OF NOTTINGHAM Contribution nette de l'UE € 183 454,80 Adresse University Park NG7 2RD Nottingham Royaume-Uni Voir sur la carte Région East Midlands (England) Derbyshire and Nottinghamshire Nottingham Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 183 454,80
