Objective
Nanoparticles , NPs, are being used to produce novel materials with unique physico-chemical properties with many applications in fields such as medicine, energy and electronics, consumer goods, among others. Some studies have revealed that the same specific properties that make NPs so unique could also be responsible for potential harmful effects on the environment and human health. Currently, the assessment of their impact is hampered by limited analytical capabilities to detect them in complex natural matrices. New sensitive and selective analytical methods must be developed and validated in order to elucidate their toxicological effects prior to increasing and promoting the NPs production. Herein, new analytical methodologies based on inductively coupled plasma mass spectrometry (ICP-MS) are proposed to evaluate the toxicity of metallic NPs in cells, one of the most powerful and attractive model systems for toxicological assays. The proposed methodology consists on the use of laser ablation (LA) coupled to ICP-MS for spatially resolved bioimaging of the distribution of NPs in single cells upon different NPs incubation experiments; furthermore, a micro-droplet generator (µDG) for sample introduction of single cells into a sector field ICP-MS will be employed to improve the NPs detection sensitivity. The expected results will give essential insights into nanoparticle/cell interactions and will have implications for the development of analytical methods based on applications of nano-particles for medical diagnostics and therapeutics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences chemical sciences inorganic chemistry transition metals
- natural sciences biological sciences biological behavioural sciences ethology biological interactions
- natural sciences chemical sciences inorganic chemistry metalloids
- natural sciences chemical sciences analytical chemistry mass spectrometry
- natural sciences physical sciences optics laser physics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
12205 Berlin
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.