GlyCoCanProject reference: 676421
Funded under :
Exploiting Glycosylation of Colorectal Cancer for the development of improved diagnostics and therapeutics
Total cost:EUR 3 293 890,92
EU contribution:EUR 3 293 890,92
Call for proposal:H2020-MSCA-ITN-2015See other projects for this call
Funding scheme:MSCA-ITN-ETN - European Training Networks
Colorectal cancer (CRC) is a major worldwide cancer burden with about 1.4 million cases in 2012 and an annual mortality of approximately 700,000. Early detection is crucial as treatment is most efficient in early stages where population based screenings could substantially reduce incidence and mortality.
Current screening techniques are invasive or lack sensitivity and specificity. Moreover, the molecular mechanisms leading to the formation of different antigens suggested as CRC biomarkers and potential therapeutic targets are poorly understood, especially with regard to carbohydrate-based molecules, such as glycans. Enhancing our understanding of the structure-function relationship of glycosylation in CRC could lead to the discovery of improved diagnostic and prognostic biomarkers and pave the way for nov-el therapeutic targets.
Building on an established network of analysts with many years of experience in (glyco)proteomics and biomarker research, in collaboration with colleagues in the field of glycobiology and glyco-immunology, GlyCoCan will develop new methods, and use current state of the art methods, to investigate the role of glycosylation in many different aspects of CRC.
The GlyCoCan multi-disciplinary network will principally be a training programme with a substantial industrial focus on technology transfer and teaching of internationally adopted biopharma regulations (GMP, ISO9001, ICH guidelines). The underlying specific research objectives will be addressed within individual ESR projects, giving rise to a generation of ESRs whose main focus is investigating and tackling the challenges of the role of glycosylation within CRC and other diseases.
The network will address the currently unmet need for glycosylation researchers with an inter-disciplinary perspective to fully exploit the immense potential of the young scientific field of glyco-oncology and to set them on a path to successful and productive careers in academic and industrial collaborations.
EU contribution: EUR 255 374,28
2333 ZA LEIDEN
EU contribution: EUR 273 287,88
CULHAM SCIENCE CENTRE - BUILDING E1
OX14 3EB ABINGDON
EU contribution: EUR 495 522
EU contribution: EUR 498 432,96
EU contribution: EUR 525 751,2
RUE MICHEL ANGE 3
EU contribution: EUR 510 748,56
1081 HV Amsterdam
EU contribution: EUR 258 061,32
VIA ZAMBONI 33
EU contribution: EUR 0
CAMPO MARTIRES DA PATRIA 130
1169 056 LISBOA
EU contribution: EUR 476 712,72
CAMPUS DE CAPARICA FACULDADE DE CIENCIAS E TECNOLOGIA DA UNIVERSIDADE NOVA DE LISBOA
2829 516 CAPARICA