Project description
Uncovering the epigenetics of memory functions
Neuroepigenetics is an emerging field that investigates epigenetic-linked processes in the context of neuronal plasticity, memory function, and brain disease. The ERC-funded DEPICODE project aims to consolidate the field of neuroepigenetics and uncover details of the mechanisms by which epigenetic processes affect memory formation under physiological and pathological conditions. The objective is to investigate how the epigenetic code is translated into cellular changes that mediate memory formation and how epigenetic mechanisms contribute to the transmission of cognitive phenotypes across generations. The results of the study will provide an understanding of the mechanisms that underlie memory formation and pave the way for the development of new therapies for age-related cognitive disorders.
Objective
The emerging field of neuroepigenetics investigates processes such as histone-acetylation in the context of
neuronal plasticity, memory function and brain diseases. My group has significantly contributed to this novel
research field. It is however fair to say that the role of “epigenetics” in memory function is still met with
some skepticism in the neurosciences, which is in part due to the fact that many of the current studies have
been describing phenomena and mechanistic data to explain how epigenetic processes control memory
function in health and disease are comparatively sparse. The major objective of this research proposal is to
address this issue and help to consolidate the field of neuroepigenetics by providing insight to the
mechanisms by which epigenetic processes contribute to memory formation under physiological and
pathological conditions. More specifically I will ask how the epigenetic code is translated into cellular
changes that mediate memory formation in health and disease and how can epigenetic mechanisms
contribute to the transmission of cognitive phenotypes even across generations. Our results will not only
provide import insight to the mechanisms that underlie memory formation but will also lay the basis for the
development of novel and improved therapies for age-related cognitive disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology cognitive neuroscience
- medical and health sciences basic medicine neurology dementia alzheimer
- medical and health sciences clinical medicine psychiatry schizophrenia
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- natural sciences biological sciences genetics epigenetics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-COG - Consolidator Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2014-CoG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
53127 Bonn
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.