Obiettivo Parkinson’s disease (PD) is one of the most prevalent neurodegenerative disorders and a disease with a significant unmet medical need. World-wide, more than 4.6 million individuals over the age of 50 suffer from PD and it is estimated that the number will more than double by 2030. The economic impact of the disease is enormous and the estimated annual European cost of PD is 14 billion euros. At present, only symptomatic therapies are available for PD and there is a huge unmet need for treatments that also slow or halt disease progression. Improved patient outcomes are achieved by early diagnosis and disease modifying treatment. BioArctic Neuroscience is developing a PD biomarker assay, with the potential of becoming the first biochemical biomarker assay that can reflect the underlying pathophysiology of disease. The assay is based on CSF measurements of toxic oligomer/protofibril forms of alpha-synuclein.In this project we will:• Conduct biochemical biomarker assay development for PD• Conduct a small pilot study on clinical cohorts including patients with PD and healthy controls• Evaluate the business opportunities and further development path for PD biomarkersToday, there are no reliable biochemical biomarkers for PD and the disease is often difficult to diagnose. The differential diagnosis of PD is based on clinical features and the golden standard still remains neuropathological confirmation. Misclassification, especially in early PD, occurs frequently. High sensitivity and specificity can only be obtained at specialized centres, and after several years of follow-up. To be able to modify or halt the disease progression it is beneficial to initiate a disease modifying treatment at an earlier stage than what is possible today. The clinical validation of a sensitive and specific biomarker that also could mirror the treatment effect would make an enormous advantage and need to be developed in parallel with the development of new disease modifying therapeutics. Campo scientifico natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicinephysiologypathophysiologymedical and health sciencesbasic medicineneurologyparkinson Parole chiave Parkinsons disease Neurodegeneration Programma(i) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.3. - Treating and managing disease Argomento(i) PHC-12-2015-1 - Clinical research for the validation of biomarkers and/or diagnostic medical devices Invito a presentare proposte H2020-SMEInst-2014-2015 Vedi altri progetti per questo bando Bando secondario H2020-SMEINST-1-2015 Meccanismo di finanziamento SME-1 - SME instrument phase 1 Coordinatore BIOARCTIC AB Contribution nette de l'UE € 50 000,00 Indirizzo WARFVINGES VAG 35 112 51 Stockholm Svezia Mostra sulla mappa PMI L’organizzazione si è definita una PMI (piccola e media impresa) al momento della firma dell’accordo di sovvenzione. Sì Regione Östra Sverige Stockholm Stockholms län Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Collegamenti Contatta l’organizzazione Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 71 429,00