Objectif Systems medicine designates the application of global approaches to human health and disease. Genomic technologies, especially next-generation sequencing, are already pioneering this new area. There is an urgent need to advance proteomics technologies to a similar level. This will help revolu¬tionize diagnosis and prognosis based on the expression levels and modifications of proteins in cells, tissues, organoids or body fluids. Our vision is to make mass spectrometry so robust and powerful that it will be present in every biological laboratory and in every clinic. The applicants are leaders in proteomics technologies from academia and industry and have an out-standing track-record in advancing both instrumentation as well as its application in biological and disease contexts. Here we come together to develop breakthrough technology capable of more than a factor ten improvement in parameters of performance of the mass spectrometric workflow, ena¬bling patient-oriented proteome profiling. The proteomics workflow will be automated, multiplexed and made ‘industrial strength’ - ready for high-throughput and in-depth clinical applications. Importantly, in addition to the identification of the main protein representative of a gene, we aim to routinely identify and quantify protein modifications and isoforms by using multidimensional approaches, including new separation, enrichment and frag¬mentation technologies. The breakthroughs aimed for will generate larger more biologically relevant data. This data will be merged with other ‘omic’ data and mined using machine learning technologies. Our results will establish the role mass spectrometry in systems medicine, making all workflows and mass spectrometry platforms available to the community. They will be used as the basis of myriad applications in biomedicine, even in the clinic. This in turn will lead to a new eco-system around improved diagnosis, elucidations of disease mechanisms and drug action. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health scienceshealth sciencespersonalized medicinenatural sciencesbiological sciencesecologyecosystemsnatural scienceschemical sciencesanalytical chemistrymass spectrometrynatural sciencescomputer and information sciencesartificial intelligencemachine learning Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Thème(s) FETOPEN-RIA-2014-2015 - FET-Open research projects Appel à propositions H2020-FETOPEN-2014-2015 Voir d’autres projets de cet appel Sous appel H2020-FETOPEN-2014-2015-RIA Régime de financement RIA - Research and Innovation action Coordinateur KOBENHAVNS UNIVERSITET Contribution nette de l'UE € 1 403 600,00 Adresse NORREGADE 10 1165 Kobenhavn Danemark Voir sur la carte Région Danmark Hovedstaden Byen København Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 403 600,00 Participants (3) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Allemagne Contribution nette de l'UE € 699 025,00 Adresse HOFGARTENSTRASSE 8 80539 Munchen Voir sur la carte Région Bayern Oberbayern München, Kreisfreie Stadt Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 699 025,00 UNIVERSITEIT UTRECHT Pays-Bas Contribution nette de l'UE € 700 000,00 Adresse HEIDELBERGLAAN 8 3584 CS Utrecht Voir sur la carte Région West-Nederland Utrecht Utrecht Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 700 000,00 THERMO FISHER SCIENTIFIC (BREMEN) GMBH Allemagne Contribution nette de l'UE € 870 000,00 Adresse HANNA KUNATH STRASSE 11 28199 Bremen Voir sur la carte Région Bremen Bremen Bremen, Kreisfreie Stadt Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 2 236 250,00
