Objective
Translating intracellular delivery to the market
The advent of nanotechnology allowed the combination of new chemical and physical tools to engineer carriers able to perform specific functions at the molecular level.
In recent years the ERC award ERC-STG-MEViC, helped to develop a powerful new technology called EndoNaut. This can be used to encapsulate and deliver dyes, imaging and contrast agents and drugs. EndoNaut technology consists of pH sensitive polymeric vesicles with the unique characteristics of endosomal delivery whilst maintaining cell viability and metabolic activity. The core technology, is based on the assembly in water of diblock copolymer poly(2-(methacryloyloxy)ethyl phosphorylcholine)–poly(2-(di-isopropylamino)ethyl methacrylate) (PMPC–PDPA) into vesicles (also known as polymersomes). These nanoscopic carriers enable the encapsulation of both hydrophilic and hydrophobic compounds including large biological macromolecules. Intracellular delivery is of prime importance for several applications and it can enhance existing therapies as well as allowing new ones. It is not surprising that EndoNaut is now generating significant commercial interest from several our collaborating pharmaceutical and non-pharmaceutical partners.
There are two major areas of application for EndoNaut that offer opportunity for short term commercialisation. The first application is as a reagent in life science research and the second is as screening platform for new chemical entities libraries of pharmaceutical companies with few or no other option to deliver their molecules. The world market for both intracellular reagents and high-throughput screening are predicted to grow yearly by 8-9% generating revenue in the order of billions of USD (PRNewswire). The aim of this project is to form a new company dedicated to the exploitation of EndoNaut technology. The current grant would be enabling in the translation process from laboratory to market.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-POC - Proof of Concept Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2015-PoC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
WC1E 6BT London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.