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NanoPacks: Assembling nanoparticles via evaporation-driven droplet collapse for ultrasensitive detection techniques

Objective

The foundation of nanophotonics and nanoplasmonics has boosted the development of ultrasensitive detection techniques. Some of these techniques, such as Surface Enhanced Raman Spectroscopy or Surface Enhanced Fluorescence, are able to detect femtomolar concentrations of analytes or even single molecules, only relying on the adsorption of the analytes on a nanostructured surfaces.

The development of nanotechnology requires a high control on the building blocks of the structures. The concept of self-assembly has been introduced and successfully applied in recent years to build all sorts of nanostructures. However, self-assembly generally involves an attractive interaction of the elements which requires the use of specially designed nanoparticles, thus imposing severe limitations in the applicability of self-assembly.

The approach I want to explore in this project is a complete change of paradigm which consists on assembling nanostructures through the collapse of evaporating drops: A droplet, containing both metallic nanoparticles and a tiny amount of analyte molecules, evaporates until the whole solvent vanishes and only the solutes are left. By manipulating the way the droplet evaporates, we can control the shape and properties of the remains, and therefore assemble metallic nanoparticles together with the molecules of interest in a passive way.

The project will increase the reach of plasmonic-based techniques for the early detection of diseases: First, the approach does not rely on expensive fabrication techniques, but only on the thermodynamics and the statistical physics of the particle packings. Secondly, by using a physical approach to form nanoparticle and analyte aggregates, we avoid adverse interactions with the analyte’s chemistry.

The packing of metallic nanoparticles presents new challenges and brings several scientific questions that I will address experimentally through microfluidics, but also via simulations and modeling.

Fields of science (EuroSciVoc)

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Programme(s)

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Topic(s)

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Funding Scheme

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ERC-STG - Starting Grant

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Call for proposal

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(opens in new window) ERC-2015-STG

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Host institution

UNIVERSITEIT TWENTE
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 500 000,00
Address
DRIENERLOLAAN 5
7522 NB Enschede
Netherlands

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Region
Oost-Nederland Overijssel Twente
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 500 000,00

Beneficiaries (1)

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