Objetivo Fifteen years ago it was widely believed that asthma was an allergic/atopic disease caused by allergen exposure in infancy; this produced atopic sensitization and continued exposure resulted in eosinophilic airways inflammation, bronchial hyper-responsiveness and reversible airflow obstruction. It is now clear that this model is at best incomplete. Less than one-half of asthma cases involve allergic (atopic) mechanisms, and most asthma in low-and-middle income countries is non-atopic. Westernization may be contributing to the global increases in asthma prevalence, but this process appears to involve changes in asthma susceptibility rather than increased exposure to “established” asthma risk factors. Understanding why these changes are occurring is essential in order to halt the growing global asthma epidemic.This will require a combination of epidemiological, clinical and basic science studies in a variety of environments. A key task is to reclassify asthma phenotypes. These are important to: (i) better understand the aetiological mechanisms of asthma; (ii) identify new causes; and (iii) identify new therapeutic measures. There are major opportunities to address these issues using new techniques for sample collection from the airways (sputum induction, nasal lavage), new methods of analysis (microbiome, epigenetics), and new bioinformatics methods for integrating data from multiple sources and levels. There is an unprecedented potential to go beyond the old atopic/non-atopic categorization of phenotypes. I will therefore conduct analyses to re-examine and reclassify asthma phenotypes. The key features are the inclusion of: (i) both high and low prevalence centres from both high income countries and low-and-middle income countries; (ii) much more detailed biomarker information than has been used for previous studies of asthma phenotypes; and (iii) new bioinformatics methods for integrating data from multiple sources and levels. Ámbito científico medical and health sciencesclinical medicinepneumologyasthmamedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesclinical medicinedermatologysocial sciencessociologyanthropologyscience and technology studiesmedical and health sciencesclinical medicineallergology Programa(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Tema(s) ERC-ADG-2014 - ERC Advanced Grant Convocatoria de propuestas ERC-2014-ADG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-ADG - Advanced Grant Institución de acogida LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER Aportación neta de la UEn € 1 067 832,00 Dirección KEPPEL STREET WC1E 7HT London Reino Unido Ver en el mapa Región London Inner London — West Camden and City of London Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 1 067 832,00 Beneficiarios (6) Ordenar alfabéticamente Ordenar por aportación neta de la UE Ampliar todo Contraer todo LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER Reino Unido Aportación neta de la UEn € 1 067 832,00 Dirección KEPPEL STREET WC1E 7HT London Ver en el mapa Región London Inner London — West Camden and City of London Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 1 067 832,00 UNIVERSIDADE FEDERAL DA BAHIA Brasil Aportación neta de la UEn € 255 882,00 Dirección RUA AUGUSTO VIANNA SN CANELA 40110-060 Salvador Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 255 882,00 UNIVERSITY OF BRISTOL Reino Unido Aportación neta de la UEn € 269 141,00 Dirección BEACON HOUSE QUEENS ROAD BS8 1QU Bristol Ver en el mapa Región South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 269 141,00 ST GEORGE'S HOSPITAL MEDICAL SCHOOL Reino Unido Aportación neta de la UEn € 255 880,00 Dirección CRANMER TERRACE SW17 0RE London Ver en el mapa Región London Inner London — West Wandsworth Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 255 880,00 UNITED KINGDOM RESEARCH AND INNOVATION La participación finalizó Reino Unido Aportación neta de la UEn € 30 093,00 Dirección POLARIS HOUSE NORTH STAR AVENUE SN2 1FL Swindon Ver en el mapa Región South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Swindon Tipo de actividad Research Organisations Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 30 093,00 MASSEY UNIVERSITY Nueva Zelanda Aportación neta de la UEn € 469 975,00 Dirección TENNENT DRIVE 4442 Palmerston North Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 469 975,00
