Objective
The currently available heart valve prostheses do not consist of living tissue and, hence, they cannot grow, repair, and remodel in response to changing demands. This restricts the use of valve replacements in pediatric patients, since they need multiple reoperations to accommodate somatic growth. Tissue-engineered heart valves (TEHVs) may be able to overcome this limitation due to their growth and remodeling potential. However, the exact growth and remodeling processes remain poorly understood, which has become evident in many pre-clinical studies where TEHVs lost their functionality over time due to adverse tissue remodeling.
The goal of this proposal is to unravel the mechanisms of tissue growth in native valves and TEHVs by integrating advanced continuum mechanics and cell biology, in order to develop predictive models of valve growth that can guide and optimize tissue engineering of heart valves. To achieve this goal, I will first be trained in developing continuum models of valve growth in the lab of Dr. Kuhl at Stanford University, who is a leading expert in modeling soft tissue growth. Furthermore, I will be trained in cell biology and mechanobiology which will enable me to develop agent-based mechanobiological models as a driving mechanism for valve growth in the continuum models.
I will use the obtained knowledge to analyze and predict growth of TEHVs in Europe. At this moment, mechanistic models of valve growth are not available. The models that I will develop during and after my training will provide crucial information for designing TEHVs with long-term functionality and growth potential, and will boost European excellence and competitiveness in the fields of biomechanics and tissue engineering. Moreover, the training that I will receive will significantly extend my scientific profile, and it will provide me the valuable international training at a prestigious academic institute that is required for pursuing an academic career in Europe.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- medical and health sciences medical biotechnology tissue engineering
- natural sciences biological sciences biophysics
- natural sciences mathematics pure mathematics geometry
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-GF - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
5612 AE Eindhoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.