Objective
Our daily life is a complex chain of decisions and actions that shapes our behaviors. Individuals tend to choose the best action possible among different alternatives through “goal-directed” decision-making. Given that action-selection is supposed to occur on the basis of the individual subjective evaluation of the relative costs and benefits of each action, two types of information need to be integrated within choice-specific neuronal representations: the causal consequences of an action (outcome) and the value of the outcome. The prefrontal cortex (PFC) appears to be well suited to organize such action-selection. However, despite the growing interest in decision-making over the past few years, the neuronal and synaptic mechanisms underlying goal-directed action-selection in normal and pathological conditions remain elusive. By using two-photon imaging over long-time frames in behaving mice, our project will first determine how alternative choices are encoded by specific neuronal representations in the PFC, and how they are compared during decision-making to select to best action possible. To achieve flexible behaviors in a dynamic environment, individuals must rapidly update these representations according to the difference between the predicted and the obtained outcome. Many cortical and subcortical structures act in coordination to encode and process changes in the outcome value, but the synaptic underpinnings remain unknown. Our proposal will take full advantage of in vivo methods combining electrophysiology, optogenetic and genetically-encoded calcium indicators to address the causal relationship between subcortical population dynamics and prefrontal neuronal processing during decision-making and behavioral flexibility. Finally, given that motivational alterations are observed in many human neuropsychiatric disorders including autism, we will tackle synaptic, cellular and behavioral decision-making deficits in a mouse model of autism.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences neurobiology
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences physical sciences optics microscopy
- natural sciences computer and information sciences data science data processing
- natural sciences biological sciences molecular biology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-STG - Starting Grant
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2015-STG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.