NoCanTherProject reference: 685795
Funded under :
Nanomedicine upscaling for early clinical phases of multimodal cancer therapy
During the last four years the Multifun Consortium (FP7 project Nº. 262943) has developed and validated distinct nanoformulations as therapeutic approach against pancreatic and breast cancer. These nanoformulations are based on magnetic iron oxide nanoparticles (MNP) multifuntionalised with a target peptide and an anticancer chemical drug, allowing for a synergistic therapeutic effect produced by the combination of intracellular drug delivery and magnetic hyperthermia. In particular, some of the designed formulations (patent filed PCT/EP2015/056631) have proven their efficacy, safety and non-toxicicty, in in vitro and in vivo studies, against the mentioned cancers, thus making them promising candidates to produce a novel nanomedicine therapy for cancer.
NoCanTher aims at translating one of these nanoformulations to early clinical development for pancreatic cancer. To successfully reach this objective, we will concentrate our efforts in two main group of activities:
• Nanomedicine up-scaling under GMP conditions: NoCanTher will scale up the manufacturing of the proposed nanoformulation from milligram-scale laboratory synthesis up to multigram-scale production to generate sufficient material for clinical and regulatory assays. To this aim, a GMP production line will be optimised and the relevant quality control will be conducted at the different stages of the up-scaling process.
• Clinical trial: NoCanTher will include late preclinical parameter testing to raise a clinical treatment protocol, regulatory assays, as well as the design of the clinical trial and the preparation of the Investigational Medicinal Product Dossier (IMPD).
This strategy will allow us to apply for Clinical Trial Authorisation (CTA) then, we will carry out a Phase I clinical trial.
NoCanTher involves the participation of institutions from three different sectors (academia, industry, clinical) and from five different countries (Ireland, France, Germany, Spain and the UK).
EU contribution: EUR 665 000
CIUDAD UNIVERSITARIA DE CANTOBLANCO - CALLE FARADAY 9
EU contribution: EUR 1 302 240
CALLE HERMANOS LUMIERE 5 PARQUE TECNOLOGICO DE ALAVA
01510 MINANO ALAVA
EU contribution: EUR 427 820
SW1H 0RG LONDON
EU contribution: EUR 400 000
EU contribution: EUR 649 017,5
Melchor Fernández Almagro
E-28029 Madrid Madrid
EU contribution: EUR 765 125
EU contribution: EUR 700 000
ALBERMALE STREET THE ROYAL 21
W1S 4BS LONDON
EU contribution: EUR 549 441,25
PASSEIG VALL D HEBRON 119-129 EDIFICIO DE RECERCA
EU contribution: EUR 691 847,5
EU contribution: EUR 611 000
RUE THOMAS MANN 5
EU contribution: EUR 352 287,5
CALLE NAZARET 115-117