PRECIOUSProject reference: 686089
Funded under :
Scaling-up biodegradable nanomedicines for multimodal for multimodal precision cancer immunotherapy
PRECIOUS aims at scaling-up biodegradable nanomedicines for multimodal precision cancer immunotherapy.
With 3.5 million cancer patients in Europe every year, new cancer medicines are eagerly awaited, notably for prostate and ovarian cancer.
Systemically applied new immunotherapies are promising, but their toxicity is a hurdle. Vaccination against cancer is safe but rather disappointing: the microenvironment shuts down anti-tumour immunity.
PRECIOUS will tackle 2 bottlenecks:
1. Production of non toxic multimodal nanomedicines, which induce vigorous immune responses, and at the same time reverse immunosuppression
2. Large scale GMP production of nanomedicines, and initiate multimodal immunotherapy Phase I trials.
We want to solve these bottlenecks by:
Objective 1: Two types of GMP biodegradable nanoparticles: 1) a nanovaccine, containing tumour antigens and immune activators, and 2) a nanoparticle composed of compounds, which reverses the suppression and reactivates immunity in the tumour.
Objective 2: Clinical Phase I trials to show efficacy. Both nanomedicines will be used by 1) local delivery of vaccines in lymphnodes to evoke immune responses and 2) local injection of nanoparticles in the tumour microenvironment, which slowly release compounds that reverse suppression.
To achieve this, a platform is formed with 6 leading industrial partners to produce large scale GMP nanomedicines and an excellent immunomodulator track record, together with 5 renowned academic partners to perform clinical studies. Local delivery will avoid toxicity, reduce dose, lower costs by 75%, and have major impact on the European health care system
Relevance to call: Large scale GMP production, industrial leadership, nanotechnology and advanced manufacturing KET technologies, translation to the clinic, marketing development.
EU contribution: EUR 1 413 750
GEERT GROOTEPLEIN NOORD 9
6525 EZ NIJMEGEN
EU contribution: EUR 1 065 212,5
RELLINGHAUSER 1 11
EU contribution: EUR 982 500
RUE AUGUSTE PICCARD 48
EU contribution: EUR 250 000
WC2R 1DJ LONDON
EU contribution: EUR 637 500
ZWIRKI I WIGURY 101
02 089 WARSZAWA
EU contribution: EUR 745 668,75
SCIENCE PARK 408
1098 XH AMSTERDAM
EU contribution: EUR 851 875
EU contribution: EUR 479 000
HEYROVSKEHO NAM. 2
16206 PRAHA 6
EU contribution: EUR 1 008 211,25
University Offices, Wellington Square
OX1 2JD OXFORD
EU contribution: EUR 707 500
Via Venezian 1
EU contribution: EUR 150 000
P.C. STAALWEG 30
3721 TJ BILTHOVEN