Objective
"Positive cancerous margins after surgery lead to an increased risk of progression and reduced disease free survival. Obtaining clear margins of cancerous lesions can be very challenging during surgery. Raman spectroscopy is a unique label-free optical technique based on inelastic light scattering that offers tissue ""optical biopsy"" at the molecular level. IMAGINE is a multidisciplinary approach that aims to develop the first widefield near-infrared (NIR) Raman imaging probe for intraoperative margin assessment. A new ultra-high sensitive InGaAs focal plane array (FPA) camera integrated with a novel combination of band-pass filters will be integrated to selectively probe the biomolecular constituents of tissues in the high-wavenumber range (i.e. 2800-3600 cm-1) providing a new endogenous biomolecular contrast mechanism for visualisation of resection margins during cancer surgery. A prototype will be developed and applied ex vivo on excised tissues from colorectal cancer patients. Histopathology will serve as gold standard and the sensitivity, specificy, receiver operating characteristics (ROCs), tumour contrast, and potential clinical/surgical impact will be evaluated. The new optical bioimaging modality proposed here constitutes a simple non-invasive cost-effective and broadly applicable technique for margin assessment of cancers compatible with in vivo laparoscopic settings. This translationally driven project fosters multidisciplinary research involving bioengineering, optical engineering and clinical research and has the support of a strong international industrial secondment. IMAGINE will enhance the mobility and innovative potential of the applicant and open new avenues in cancer surgery, which will strengthen the scientific excellence in Europe and ultimately benefit the patients."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- medical and health sciences medical biotechnology tissue engineering
- medical and health sciences clinical medicine surgery surgical procedures
- medical and health sciences clinical medicine oncology colorectal cancer
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.