Objective
The CA3 subregion of the hippocampus is crucial for the formation of episodic memories on a short timescale, possibly due to synaptic plasticity in the recurrent connections between pyramidal cells. Previously, in vivo observations of these changes due to a learning event were elusive; however, in the current proposal we will use new methods to allow us to observe and manipulate the changes that occur in cells and synapses correlated with memory formation. To achieve this, we will combine optogenetic stimulation techniques with both intra- and extracellular in vivo electrophysiology to measure cellular properties, network dynamics, and both artificially- and naturally-induced synaptic plasticity. Additionally, we will restrict optogenetic expression to only those cells involved in the memory, allowing us to selectively identify and manipulate these cells. Stimulation of a subset of CA3 pyramidal cells while recording the intracellular trace from an individual CA3 pyramidal cell will provide the first insights into the nature of the recurrent network in vivo; incorporating stimulation protocols designed to induce synaptic plasticity will allow us to characterize different forms of plasticity in vivo. Adding stimulation of DG inputs to this protocol will allow us to measure the modulation of both activity and synaptic plasticity. Finally, we will test the effect of natural learning on the CA3 network, by recording extracellular activity in vivo, and taking measurements of cellular properties and synapse strength ex vivo. This project will allow us, for the first time, to link the single-synapse changes hypothesized to be crucial for memory with whole-animal learning.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine neurology epilepsy
- natural sciences biological sciences neurobiology cognitive neuroscience
- medical and health sciences basic medicine neurology dementia alzheimer
- medical and health sciences clinical medicine psychiatry posttraumatic stress disorder
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
33000 BORDEAUX
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.