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Asymmetric Catalysis with Chiral Silylium Cations

Objective

In the frame of this research program, carried out at the Institute of Molecular Sciences (ISM) within the University of Bordeaux (UB), we propose the development of new powerful Lewis acid catalysts for asymmetric synthesis. The activation of small molecules (H2, CO2) and less-reactive compounds in catalytic processes is one of the central tasks of modern synthetic chemistry. This task is of fundamental and practical interest as well as of environmental significance, a central issue for our society. Purpose of the suggested research proposal is the synthesis of tailor-made chiral silyl cationic compounds with exceptional but controlled reactivity. Various molecular test systems are suggested to identify the parameters that allow efficient control over the reactivity of these silyl cations. These model systems will be applied as catalysts in organic model reactions including Diels-Alder, Mukaiyama and hydrogenation processes. The major objective of this proposal is the generation and studies of chiral silyl cations and their weakly coordinating anions in an effort to combine their inherent high reactivity with enantioselective processes. The use of chiral silyl cations as efficient Lewis acid catalysts in organic transformations should have significant impact on enantioselective organic synthesis.
Key objectives of this research program are the development of new strong activators for an efficient synthesis of chiral molecules and the training of future leading experts in the field of catalysis, a domain in which Europe must remain competitive in the 21st century as the demand for new chiral molecules and materials is increasing in domains ranging from health to energy.

Fields of science (EuroSciVoc)

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Programme(s)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-IF-EF-ST - Standard EF

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-IF-2015

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Coordinator

UNIVERSITE DE BORDEAUX
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 173 076,00
Address
PLACE PEY BERLAND 35
33000 BORDEAUX
France

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Region
Nouvelle-Aquitaine Aquitaine Gironde
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 173 076,00
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