Obiettivo "In this Marie Skłodowska-Curie Fellowship project entitled “Multi-SIP Hydrogel” I will design a modular synthetic platform for preparing multifunctional self-immolative polymer (SIP) hydrogels designed to accelerate tissue regeneration in chronic skin wounds. The hydrogels will contain multiple SIP components, each designed to rapidly degrade and deliver a therapeutic payload in response to a specific biochemical stimulus typical of a chronic wound (e.g. reactive oxygen species or enzymatic action). During the two years of this Fellowship, I aim to establish a proof-of-principle SIP-hydrogel system that will undergo sequential stimuli-responsive degradation and promote cell proliferation in vitro. This Fellowship will be undertaken under the supervision of Prof. Molly Stevens in the Division of Biomaterials and Regenerative Medicine at the Karolinska Institute (KI), which has the world-leading expertise in polymer chemistry, biomaterials engineering, cell biology and tissue engineering crucial to the objectives of the proposed work plan. Due to the modular design of the ""Multi-SIP Hydrogel"" platform, there is broad scope for designing SIP-hydrogels matched to different tissue types once a proof-of-principle is established. This will initiate new research areas at the cutting edge of biomaterials science, which will help me to establish my own independent research career following the proposed Fellowship." Campo scientifico medical and health scienceshealth sciencespublic healthmedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesclinical medicineendocrinologydiabetesnatural scienceschemical sciencespolymer sciencesmedical and health scienceshealth sciencesnutritionobesity Programma(i) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Argomento(i) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Invito a presentare proposte H2020-MSCA-IF-2015 Vedi altri progetti per questo bando Meccanismo di finanziamento MSCA-IF-EF-ST - Standard EF Coordinatore KAROLINSKA INSTITUTET Contribution nette de l'UE € 173 857,20 Indirizzo Nobels Vag 5 17177 Stockholm Svezia Mostra sulla mappa Regione Östra Sverige Stockholm Stockholms län Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 173 857,20