Luminescent Polymer Nanoparticles with Aza-BODIPYs, Porphyrins and their Metal Complexes for FRET Mediated Ratiometric Oxygen Sensing

Projektinformationen

NanoOxySens

ID Finanzhilfevereinbarung: 705826

DOI 10.3030/705826

Abgeschlossenes Projekt

EK-Unterschriftsdatum 29 Februar 2016

Startdatum 15 Mai 2017

Enddatum 14 Mai 2019

Finanziert unter

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Gesamtkosten € 185 076,00

EU-Beitrag € 185 076,00

Koordiniert durch

UNIVERSITE DE STRASBOURG
France

Ziel

This proposed Fellowship brings together an Experienced Researcher from India with expertise in the synthesis of photosensitizers and their photophysical characterization, tuning the excited-state properties, investigation of their photophysics and photobiology with an internationally recognized Host Laboratory in France with expertise in designing fluorescent molecular and nanoparticle probes for bioimaging. This project will provide (i) interdisciplinary training of highest quality to become an outstanding scientist with excellent publication record; (ii) enhance European excellence in organic synthesis, nanosciences and biophotonics. The aim of the research project is to obtain ratiometric probes for molecular oxygen based on biodegradable polymeric nanoparticles (NPs) bearing far-red/near-infrared absorbing triplet sensitizers such as aza-BODIPYs, porphyrins and corresponding metal complexes. The project involves the synthesis of phosphorescent dyes (aza-BODIPY/porphyrins) and formulation of polymeric NPs encapsulating these dyes. The development of ultra-bright polymer nanoparticles, an innovative method recently discovered in the Host Laboratory, will enable the development of novel dual emissive polymeric NPs with the triplet sensitizers. In our design, fluorescent NPs excite triplet sensitizers through energy transfer (FRET), resulting in dual emission: fluorescence of NPs and phosphoresce of the sensitizer. Only phosphorescence of FRET acceptor is sensitive to molecular oxygen (3O2), which provides the mechanism of dual colour ratiometric response to oxygen. The approach will be further validated in solutions and in living cells. The obtained nanoprobes for oxygen will be applied to living cell and (in collaboration) to whole animals. It is our strong conviction that the possibilities of this multidisciplinary chemistry are enormous, and the end result will be the development of a simple nano-device for molecular oxygen build from biodegradable materials.

Wissenschaftliches Gebiet

• natural sciences › chemical sciences › inorganic chemistry › transition metals
• natural sciences › chemical sciences › polymer sciences
• natural sciences › physical sciences › optics › microscopy
• medical and health sciences › clinical medicine › oncology
• engineering and technology › nanotechnology › nano-materials

Programm/Programme

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thema/Themen

• MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF)

Aufforderung zur Vorschlagseinreichung

H2020-MSCA-IF-2015

Finanzierungsplan

MSCA-IF-EF-ST - Standard EF

Koordinator

UNIVERSITE DE STRASBOURG

• Netto-EU-Beitrag: € 185 076,00
• Adresse: RUE BLAISE PASCAL 4 ; 67081 Strasbourg ; Frankreich
• Region: Grand Est › Alsace › Bas-Rhin
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: € 185 076,00