Objectif Panama disease is a devastating disease of banana caused by the fungus Fusarium oxysporum f.sp. cubense. A new race called tropical race 4 (TR4) is estimated to threaten >80% of the world’s bananas and can cause up to 100% yield loss. The disease is detrimental to global banana production, but also for small-holder farmers especially in Africa, because Panama disease also affects plantain cultivars that provide food for approximately 400 million people. In the 1950s, Panama Disease almost wiped out commercial banana cultivation in Central America. Because the fungus is a vascular pathogen, there is no effective way of combating the disease with crop protection compounds. In addition, the fungus can persist in the soil for many years. Traditional breeding of banana is time consuming and has had only limited success in delivering acceptable cultivars and effective resistance. The key objectives of this proposal are to employ state-of-the-arts biotechnological solutions such as genome editing using CRISPR/Cas and high-throughput resistance gene engineering to introduce a resistance gene and deactivate a susceptibility gene in banana with the global aim of creating a banana cultivar that is resistant to Panama disease. Champ scientifique medical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesmicrobiologymycologymedical and health scienceshealth sciencesnutritionagricultural sciencesagriculture, forestry, and fisheriesagriculture Mots‑clés banana genome editing Panama Disease Fusarium oxysporum resistance engineering CRISPR Cas pathogen resistance plant breeding Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Thème(s) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Appel à propositions H2020-MSCA-IF-2015 Voir d’autres projets de cet appel Régime de financement MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinateur THE SAINSBURY LABORATORY Contribution nette de l'UE € 183 454,80 Adresse Norwich Research Park, Colney Lane NR47UH Norwich Royaume-Uni Voir sur la carte Région East of England East Anglia Norwich and East Norfolk Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 183 454,80