Objective
The formation of episodic (unique event) memories is based on the interaction between the hippocampus and the cortical regions that receive its output. The major hippocampal output cells are pyramidal cells (PCs) in area CA1. In rodents, populations of CA1 PCs are known to represent a wide range of aspects associated with an episodic memory: Some cells participate in the formation of a map-like representation of space, while others additionally or exclusively encode items within the environment, represent meaningful locations, or participate in the representation of emotional and behavioural contexts. It is not known so far how heterogeneous CA1 firing patterns are organized and affect memory formation. While CA1 PCs have been traditionally considered a homogeneous cell population, we now have clear evidence for the presence of at least two distinct CA1 PC cell types that differ in their local and long-range connectivity, in their morphology, their molecular makeup and their basic firing patterns. This strongly argues for a functional specialization within the CA1 area. However, a link between the heterogeneous representation of mnemonic information and the presence of anatomically distinct PC types remains to be established. In this proposal I aim to determine whether heterogeneous response properties of CA1 PCs are based on computations in distinct anatomical microcircuits in deep and superficial layers by combining optogenetic and chemogenetic techniques with in vivo recordings in behaving mice. Furthermore, I will seek to obtain detailed knowledge about the functional connectivity between different CA1 PC populations and their target areas. Knowledge about the function of individual CA1 microcircuits and their anatomical connections is the prerequisite to subsequently develop an independent research plan aiming to determine how intra-hippocampal processing affects memory formation in their downstream targets.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine neurology epilepsy
- natural sciences biological sciences neurobiology cognitive neuroscience
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences chemical sciences organic chemistry alcohols
- natural sciences computer and information sciences artificial intelligence computational intelligence
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-RI - RI – Reintegration panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
69120 HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.