Objective Aging drives cognitive impairment and general health demise increasing the susceptibility to neurodegenerative disorders in healthy individuals. It is also associated with changes in the gut-microbiota and a general increase in the secretion of stress hormones, known to have debilitating effects when sustained. The gut-microbiota has recently emerged has a crucial modulator of cognitive abilities and general health. Nonetheless, the causes and consequences of the gut-microbiota changes seen in aging are currently unknown. In this application, we propose to study the importance of the age-associated gut-microbiota changes on brain functions, by swapping the gut-microbiota from aged mice into young mice and vice-versa. This will allow knowing the contribution of the gut-microbiota in the cognitive decline and depressive state associated with aging. Furthermore, we will test if the increase in stress hormones known to occur during aging are upstream of those age-associated microbiota changes, by testing the involvement of the amygdala to the hypothalamus-adrenal axis in this phenomena. This will be achieved by using a chemo-genetic approach to control the activation of each component of this pathway. This project will provide the first description of the functional repercussions of the age-associated changes in the gut-microbiota composition on learning and memory deficits and depression, and possibly elucidate one of the upstream mechanisms responsible. The outcome of this work will pave the way toward the elaboration of probiotic treatments against the detrimental effect of aging. Fields of science medical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicineimmunology Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Call for proposal H2020-MSCA-IF-2015 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator INSTITUT PASTEUR Net EU contribution € 185 076,00 Address RUE DU DOCTEUR ROUX 25-28 75724 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 185 076,00
