Objetivo Demographic analyses predict that one third of the 10 millions Belgian population in 2050 will be above 60 years of age. Since aging is the major risk factor for Alzheimer’s disease (AD), this increase in the proportion of seniors is closely linked to the increased prevalence of AD. With the advent of promising symptomatic treatment, it is critical to diagnose AD at its earliest stages, that is, before behavioral consequences of cognitive deficits. A systematic assessment of the cognitive state of older adults might be a promising strategy to uncover, as early as possible, individuals at higher risk of pathological aging.However, this approach raises an important issue: attentional, comprehension, decisional or motivational processes are likely to affect behavioral performance in conventional neuropsychological tests used for the diagnostic, both in AD or typical elderly individuals. The aim of this project is to develop implicit measures of memory encoding for the early diagnosis of AD that are not contaminated by non-mnesic factors. We will use an entirely novel paradigm in electroencephalography: the Fast Periodic Visual Stimulation (FPVS), which relies on the exact synchronization of the human brain to a visual stimulus repeated at a periodic rate. We will apply the FPVS approach to identify early deficits in visual memory encoding/storage in aged individuals. This will be achieved by comparing electrophysiological measures of healthy elderly with and without neuropsychological deficits, and MCI/AD patients. We will perform longitudinal assessments of implicit measures of visual discrimination and memory encoding, to evaluate the test-retest reliability of implicit measures and to examine the sensibility of implicit measures to predict the risk of evolution from MCI to AD. Implicit measures of memory encoding will be correlated with neuroimaging data and biomarkers of AD. Ámbito científico natural sciencesbiological sciencesneurobiologycognitive neurosciencemedical and health sciencesbasic medicineneurologydementiaalzheimersocial sciencessociologysocial issuessocial inequalitiesmedical and health sciencesbasic medicinepathologysocial sciencespsychologycognitive psychology Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Convocatoria de propuestas H2020-MSCA-IF-2015 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF-EF-ST - Standard EF Coordinador UNIVERSITE CATHOLIQUE DE LOUVAIN Aportación neta de la UEn € 160 800,00 Dirección PLACE DE L UNIVERSITE 1 1348 Louvain La Neuve Bélgica Ver en el mapa Región Région wallonne Prov. Brabant Wallon Arr. Nivelles Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 160 800,00
