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Deciphering cell heterogeneity in tumors using arrays of nanowires to controllably poke single cells in longitudinal studies

Objective

Cancer is responsible for 20% of all deaths in Europe. Current cancer research is based on cell ensemble measurements or on snapshot studies of individual cells. However, cancer is a systemic disease, involving many cells that interact and evolve over time in a complex manner, which cell ensemble studies and snapshot studies cannot grasp. It is therefore crucial to investigate cancer at the single cell level and in longitudinal studies (over time). Despite the recent developments in micro- and nanotechnologies, combined with live cell imaging, today, there is no method available that meets the crucial need for global monitoring of individual cell responses to stimuli/perturbation in real-time.
This project addresses this crucial need by combining super resolution live-cell imaging and the development of sensors, as well as injection devices based on vertical nanowire arrays. The devices will penetrate multiple single cells in a fully controlled manner, with minimal invasiveness.

The objectives of the project are:
1) To develop nanowire based-tools in order to gain controlled and reliable access to the cell interior with minimal invasiveness.
2) Developing mRNA sensing and biomolecule injection capabilities based on nanowires.
3) Performing longitudinal single cell studies in tumours, including monitoring gene expression in real time, under controlled cell perturbation.

By enabling global, long term monitoring of individual tumour cells submitted to controlled stimuli, the project will open up new horizons in Biology and in Medical Research. It will enable ground-breaking discoveries in understanding the complexity of molecular events underlying the disease. This cross-disciplinary project will lead to paradigm-shifting research, which will enable the development of optimal treatment strategies. This will be applicable, not only for cancer, but also for a broad range of diseases, such as diabetes and neurodegenerative diseases.

Fields of science (EuroSciVoc)

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Keywords

Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

ERC-COG - Consolidator Grant

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) ERC-2015-CoG

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Host institution

LUNDS UNIVERSITET
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 2 621 251,00
Address
Paradisgatan 5c
22100 Lund
Sweden

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Region
Södra Sverige Sydsverige Skåne län
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 2 621 251,00

Beneficiaries (1)

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