Skip to main content
Go to the home page of the European Commission (opens in new window)
English English
CORDIS - EU research results
CORDIS

Combining in vivo spectral biphoton imaging and multiparametric cytometry to characterize the dynamics of the innate immune response in a multiple sclerosis mouse model

Objective

Multiple sclerosis (MS) disease is dependent on an intricate interplay between the adaptive and innate immune systems. Nevertheless, none of the Food and Drug Administration-approved drugs target innate immune cells, because of their unclear roles in the disease process. However, innate immune cells implication in the MS disease is no longer put in doubt.
The mobilization, differentiation and spatial-temporal distribution of brain resident and recruited peripheral innate immune cells, in relation with clinical scores, will be analyzed, as an alternative source of disease biomarkers and therapeutic targets.
The project combines recent advances in (a) generation of multicolor transgenic reporter mice with subpopulations of cells expressing distinct fluorophores, (b) spectral bi-photon imaging to visualize the cells of interest directly in the spinal cord in living animals, at a subcellular resolution in real time, and (c) multiparametric flow cytometry to characterize over time inflammatory cell types in the spinal cord tissue after disease induction.
The activated cells converging to the neuronal lesions, as well as the delay and the effect on the neurons, will be characterized. VEGF will also be tested as potential therapeutic drug, based on the known VEGF effects on neurons and immune cells. This data will provide new insights on MS disease setting up and implicated cells, correlated with clinical scores, neuronal damages and disease progression.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

You need to log in or register to use this function

Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MSCA-IF-EF-ST - Standard EF

See all projects funded under this funding scheme

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) H2020-MSCA-IF-2015

See all projects funded under this call

Coordinator

UNIVERSITE D'AIX MARSEILLE
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 173 076,00
Address
BOULEVARD CHARLES LIVON 58 LE PHARO
13284 Marseille
France

See on map

Region
Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône
Activity type
Higher or Secondary Education Establishments
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 173 076,00
My booklet 0 0