Objetivo This project aims at predicting early cognitive decline using a neurofeedback performance endophenotype based on realtime functional magnetic resonance imaging in a population at risk for Alzheimer’s Disease (AD). It has been proven that AD biomarkers change decades before the development of symptoms. In addition, there is a lack of robust hypersensitive methods capable of predicting impending cognitive decline in healthy subjects at risk. This constitutes a crucial obstacle for the implementation of AD prevention trials. To address this, we will identify and characterize a novel neurofeedback performance endophenotype in a subsample from a cohort of 2743 cognitively healthy volunteers at risk for AD. This will be based on state-of-the-art neuroimaging technology, in combination with a novel sensitive neuropsychological test that detects subtle alterations in episodic memory, which has been validated for our cohort. Then, we will evaluate the impact on our newly developed neurofeedback performance endophenotype of factors known to be related to AD such as various clinical and lifestyle variables, amyloid deposition, genetic background (including, but not restricted to APOE4) and most importantly cognitive reserve. A specific aim is to test the hypothesis that neurofeedback performance can become a reliable proxy to measure cognitive reserve. Finally, we will develop a novel statistical predictive model, featuring all the relevant genetic and clinical variables and will assess the capacity of neurofeedback performance for predicting impending cognitive decline during a two-year period in AD descendants. Ámbito científico natural sciencesbiological sciencesneurobiologycognitive neurosciencemedical and health sciencesbasic medicineneurologydementiaalzheimerengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imagingmedical and health sciencesclinical medicinepsychiatryschizophrenianatural sciencescomputer and information sciencessoftwaresoftware applicationsvirtual reality Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Convocatoria de propuestas H2020-MSCA-IF-2015 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF-EF-ST - Standard EF Coordinador FUNDACIO BARCELONABETA BRAIN RESEARCH CENTER Aportación neta de la UEn € 158 121,60 Dirección CALLE WELLINGTON 30 08005 Barcelona España Ver en el mapa Región Este Cataluña Barcelona Tipo de actividad Research Organisations Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 158 121,60