Objective
Age-related remodeling of the aorta is associated with alterations in morphology and hemodynamics . These alterations are involved and accelerated in the presence of cardiovascular diseases (CVDs), suggesting that they are the likely culprits that underlie the increased cardiovascular risk associated with ageing . However, an advanced characterization of the age-related morphological/hemodynamic alterations and on their synergistic interplay is missing, mainly because encumbered by time-consuming operator-dependent tasks. In this 36 months global fellowship (University of Toronto, Canada and Politecnico di Torino, Italy), the potential clinical utility of such a characterization will be addressed, developing tools for the quantitative assessment of the age-associated alterations in a large-scale cross-sectional dataset of aortas from subjects with successful ageing. After training on phase-contrast magnetic resonance imaging (PCMRI) technique, for each subject the 4D velocity field will be acquired. Quantitative morphometric parameters will be defined and evaluated in vivo. To investigate aortic hemodynamics, PCMRI will be complemented by computational fluid dynamics (CFD) to overcome PCMRI limitations on temporal/spatial resolution and wall shear stress quantification . The impact of CFD assumptions will be assessed by validating CFD results with PCMRI measurements. To improve CFD results accuracy, in the return phase PCMRI data will be incorporated into the numeric simulations, through the assimilation of the acquired flow fields into the CFD solver. Descriptors quantifiable in vivo and able to simplify the understanding of the complex 4D hemodynamic and of age-associated remodeling will be defined. The new tools for diagnostic/prognostic purposes will be integrated within the open-source Vascular Modelling ToolKit, to facilitate and streamline the diagnosis and monitoring of a wider range of CVDs when applied to other vascular districts (e.g. carotid, aneurysm).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine integrative and complementary medicine
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- natural sciences physical sciences classical mechanics fluid mechanics fluid dynamics computational fluid dynamics
- natural sciences mathematics pure mathematics geometry
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2014
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
10129 Torino
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.