Objectif Separation and purification of biopharmaceuticals is today one of the most time and cost intense Downstream Processing (DSP) operations in the manufacture of commercial products. Separation and purification of proteins is usually achieved chromatographically, with all of its disadvantages including high buffer requirements, large footprint, reuse and storage of resin studies as well as costs. Traditional DSP based on batch chromatography contribute ca. 66% of the total production cost of anti-cancer monoclonal antibodies (mAbs). Largely contributing to this is the cost of chromatography media; for instance, the cost of 1 L of protein A resin with binding capacity of 20-70 g mAb is about 25000 Eur. By a visionary and ambitious combination of the emerging Continuous Manufacturing Paradigm with innovative Membrane Crystallization Technology and the selective nanotemplate-recognitions directly from the fermentation broth, the AMECRYS Network aims to develop a new Continuous Template-Assisted Membrane Crystallizer in order to revolutionize the DSP platform for mAbs production, thus achieving unprecedented purification and manufacturing efficiencies. Major research challenges will include: i) the synthesis of 3D-nanotemplates with specific molecular recognition ability towards mAbs from complex solutions; ii) the development of tailored macroporous fluoropolymer membranes for advanced control of selective heterogeneous nucleation; iii) the design of multilevel microfluidic devices for high-throughput mAb crystallization screening in a wide range of conditions under continuous flow (“pharma-on-a-chip” concept); iv) technology scale-up to a L-scale continuous prototype designed with recognition of QS/GMP compliance for biopharmaceuticals. The replacement of chromatography with a single membrane-crystallization unit will lead to >60% CapEx and O&M costs decrease, 30-fold footprint reduction and high-purity solid formulation of mAbs with preserved biological activity. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsengineering and technologyindustrial biotechnologybioprocessing technologiesfermentation Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Thème(s) FETOPEN-RIA-2014-2015 - FET-Open research projects Appel à propositions H2020-FETOPEN-2014-2015 Voir d’autres projets de cet appel Sous appel H2020-FETOPEN-2014-2015-RIA Régime de financement RIA - Research and Innovation action Coordinateur CONSIGLIO NAZIONALE DELLE RICERCHE Contribution nette de l'UE € 608 073,75 Adresse PIAZZALE ALDO MORO 7 00185 Roma Italie Voir sur la carte Région Centro (IT) Lazio Roma Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 608 073,75 Participants (8) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Royaume-Uni Contribution nette de l'UE € 368 125,00 Adresse SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON Voir sur la carte Région London Inner London — West Westminster Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 368 125,00 UNIVERSITA DELLA CALABRIA Italie Contribution nette de l'UE € 375 000,00 Adresse VIA PIETRO BUCCI 7/11/B 87036 Arcavacata Di Rende Voir sur la carte Région Sud Calabria Cosenza Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 375 000,00 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Contribution nette de l'UE € 274 115,00 Adresse RUE MICHEL ANGE 3 75794 Paris Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 274 115,00 UNIVERSITE LIBRE DE BRUXELLES Belgique Contribution nette de l'UE € 299 375,00 Adresse AVENUE FRANKLIN ROOSEVELT 50 1050 Bruxelles / Brussel Voir sur la carte Région Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 299 375,00 UNIVERSITY OF STRATHCLYDE Royaume-Uni Contribution nette de l'UE € 335 500,00 Adresse Richmond Street 16 G1 1XQ Glasgow Voir sur la carte Région Scotland West Central Scotland Glasgow City Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 335 500,00 CENTRE FOR PROCESS INNOVATION LIMITED LBG Royaume-Uni Contribution nette de l'UE € 705 015,46 Adresse WILTON CENTRE WILTON TS10 4RF Redcar Cleveland Voir sur la carte Région North East (England) Tees Valley and Durham South Teesside Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 705 015,46 GVS SPA Italie Contribution nette de l'UE € 291 250,00 Adresse VIA ROMA 50 40069 Zola Predosa Voir sur la carte Région Nord-Est Emilia-Romagna Bologna Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 291 250,00 FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED Royaume-Uni Contribution nette de l'UE € 277 359,54 Adresse BELASIS AVENUE TS23 1LH BILLINGHAM Voir sur la carte Région North East (England) Tees Valley and Durham Hartlepool and Stockton-on-Tees Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 277 359,54