Objective The eTOX consortium proposes to develop innovative methodological strategies and novel software tools to better predict the toxicological profiles of new molecular entities in early stages of the drug development pipeline. This will be achieved by coordinating the efforts of specialists from academia and SMEs in the wide scope of disciplines that are required to move towards a more reliable modelling of the complex relationships existingbetween molecular and in vitro information and the in vivo toxicity outcomes of drugs. The proposed strategy includes a synergetic integration of innovative approaches in the following areas:Database building and management, including masking procedures for sensitive data, with the aim of facilitating the sharing of information among pharmaceutical companies.• Ontologies and text mining techniques, with the purpose of facilitating knowledge extraction from legacy preclinical reports and biomedical literature.• Chemistry and structure-based approaches for the molecular description of the compounds considered, as well as of the biological anti-targets responsible for the secondary pharmacologies.• Prediction of absorption and metabolism since these ADME properties are often critically related to toxicological events.• Computational genomics to afford the inter-species and inter-individual variabilities that complicate the interpretation of experimental and clinical outcomes.• Systems biology approaches in order to cope with the complex biological mechanisms which govern in vivo safety problems.• Sophisticated statistical analysis tools required to derive the inevitably highly-multivariate QSAR models.• Development and validation (according to the OECD principles) of QSARs, integrative models, expert systems and meta-tools.• Linkage of toxicity preclinical data with human outcomes Fields of science natural sciencescomputer and information sciencesartificial intelligenceexpert systemsmedical and health sciencesbasic medicinetoxicologynatural sciencescomputer and information sciencesdata sciencedata processing Programme(s) FP7-JTI - Specific Programme "Cooperation": Joint Technology Initiatives Topic(s) IMI-JU-01-2008-03 - Expert Systems For In Silico Toxicity Prediction Call for proposal IMI-JU-01-2008 See other projects for this call Funding Scheme JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI) Coordinator NOVARTIS PHARMA AG EU contribution No data Address LICHTSTRASSE 35 4056 Basel Switzerland See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Barbara Stolz (Dr) Principal investigator François Pognan (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (29) Sort alphabetically Sort by EU Contribution Expand all Collapse all FUNDACIO INSTITUT HOSPITAL DEL MAR D INVESTIGACIONS MEDIQUES Spain EU contribution € 1 129 407,00 Address Doctor Aiguader 88 08003 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Andreu Fort (Mr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III Spain EU contribution € 400 025,00 Address C MELCHOR FERNANDEZ ALMAGRO 3 28029 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Laura Bertolini (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EUROPEAN MOLECULAR BIOLOGY LABORATORY Germany EU contribution € 608 090,00 Address Meyerhofstrasse 1 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Mark Green (Mr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LIVERPOOL JOHN MOORES UNIVERSITY United Kingdom EU contribution € 393 176,00 Address RODNEY STREET 2 EGERTON COURT L3 5UX Liverpool See on map Region North West (England) Merseyside Liverpool Activity type Higher or Secondary Education Establishments Administrative Contact Andrew Young (Professor) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DANMARKS TEKNISKE UNIVERSITET Denmark EU contribution € 424 352,00 Address ANKER ENGELUNDS VEJ 101 2800 Kongens Lyngby See on map Region Danmark Hovedstaden Københavns omegn Activity type Higher or Secondary Education Establishments Administrative Contact Kristina Holdgaard-Sørensen (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAT WIEN Austria EU contribution € 357 140,00 Address UNIVERSITATSRING 1 1010 Wien See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Heinz W. Engl (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING VU Netherlands EU contribution € 356 528,00 Address DE BOELELAAN 1105 1081 HV Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Yvonne Kops (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INTE:LIGAND SOFTWARE-ENTWICKLUNGS-UND CONSULTING GMBH Austria EU contribution € 256 736,00 Address CLEMENS MARIA HOFBAUER GASSE 6 2344 Maria Enzersdorf See on map Region Ostösterreich Niederösterreich Wiener Umland/Südteil Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Thierry Langer (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LHASA LIMITED United Kingdom EU contribution € 726 972,00 Address GRANARY WHARF HOUSE, 2 CANAL WHARF LS11 5PS Leeds See on map Region Yorkshire and the Humber West Yorkshire Leeds Activity type Research Organisations Administrative Contact Jan Jeremy Langowski (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MOLECULAR NETWORKS GMBH COMPUTERCHEMIE Germany EU contribution € 597 872,00 Address NEUMEYERSTR 28-34 90411 Nurnberg See on map Region Bayern Mittelfranken Nürnberg, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Desiree van’t Oever (-) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CHEMOTARGETS S.L. Spain EU contribution € 291 020,00 Address Doctor Aiguader 88 08003 Barcelona See on map Region Este Cataluña Barcelona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Mireia Manent (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Lead Molecular Design S.L. Spain EU contribution € 327 020,00 Address Av. Cerdanyola 08173 Sant Cugat del Vallès See on map Administrative Contact Begoña Terricabras (-) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASTRAZENECA AB Sweden EU contribution No data Address Vastra Maelarhamnen 151 85 Sodertaelje See on map Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eva Lindgren (-) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Bayer Pharma AG Germany EU contribution No data Address Muellerstrasse 178 13353 Berlin See on map Region Berlin Berlin Berlin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Peter Steudtner (-) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BOEHRINGER INGELHEIM INTERNATIONALGMBH Germany EU contribution No data Address BINGER STRASSE 55218 Ingelheim See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Mainz-Bingen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Marcus Kostka (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ESTEVE PHARMACEUTICALS, SA Spain EU contribution No data Address PASSEIG DE LA ZONA FRANCA 109, 4A PLANTA 08038 Barcelona See on map Region Este Cataluña Barcelona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eduard Valenti (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. United Kingdom EU contribution No data Address Great West Road 980 TW89GS Brentford See on map Region London Outer London — West and North West Hounslow and Richmond upon Thames Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Graham Sommers (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JANSSEN PHARMACEUTICA NV Belgium EU contribution No data Address TURNHOUTSEWEG 30 2340 Beerse See on map Region Vlaams Gewest Prov. Antwerpen Arr. Turnhout Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Henk Sipma (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data H. LUNDBECK AS Denmark EU contribution No data Address OTTILIAVEJ 7-9 2500 Valby See on map Region Danmark Hovedstaden Byen København Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ejner Knud Moltzen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PFIZER LIMITED United Kingdom EU contribution No data Address RAMSGATE ROAD CT13 9NJ Sandwich See on map Region South East (England) Kent East Kent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Olga Krylova (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data F. HOFFMANN-LA ROCHE AG Switzerland EU contribution No data Address GRENZACHERSTRASSE 124 4070 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jason Hannon (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UCB PHARMA SA Belgium EU contribution No data Address ALLEE DE LA RECHERCHE 60 1070 Bruxelles / Brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Simon Dresse (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SANOFI-AVENTIS DEUTSCHLAND GMBH Germany EU contribution No data Address BRUNINGSTRASSE 50 65929 Frankfurt Am Main See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Alexandra Miranville (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT DE RECHERCHES INTERNATIONALES SERVIER IRIS France EU contribution No data Address RUE CARNOT 50 92284 Courbevoie See on map Region Ile-de-France Ile-de-France Hauts-de-Seine Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jean-Luc DELONGEAS (Mr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SYNAPSE RESEARCH MANAGEMENT PARTNERS SL Spain EU contribution € 707 974,00 Address CALLE VELAZQUEZ 94 PLANTA 1 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Montse Camprubi (Ms) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Germany EU contribution € 96 600,00 Address HANSASTRASSE 27C 80686 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Andrea Zeumann (Ms) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 87 336,00 Address DR MOLEWATERPLEIN 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Sander Woerdeman (Mr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF LEICESTER United Kingdom EU contribution € 99 299,00 Address UNIVERSITY ROAD LE1 7RH Leicester See on map Region East Midlands (England) Leicestershire, Rutland and Northamptonshire Leicester Activity type Higher or Secondary Education Establishments Administrative Contact Marie Adams (Mrs) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAT POLITECNICA DE VALENCIA Spain EU contribution € 50 471,00 Address CAMINO DE VERA SN EDIFICIO 3A 46022 Valencia See on map Region Este Comunitat Valenciana Valencia/València Activity type Higher or Secondary Education Establishments Administrative Contact Andrés Moratal Roselló (Mr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data