Objective
The QuIC-ConCePT consortium has 2 objectives:
1.(90% of resource, WP2-5) to qualify 3 specific imaging biomarkers (IBs) of tumour cell proliferation, apoptosis, and necrosis, to allow drug developers to demonstrate reliably modulation of these pathologic processes in tumours in patients in realistic trials. Our vision for January 2016 is that drug developers can incorporate these IBs for decision-making in Phase I trials of investigational therapies, confident that the IBs are technically valid, that a measured change in the IB faithfully reflects the desired change in the underlying tumour pathology, and that the IBs can be readily deployed in multiple cancer centres in a robust, consistent, ethical, and cost-effective way acceptable to patients.
2.(10% of resource, WP6) includes a portfolio of innovative approaches to devise, evaluate and introduce IBs of invasion and metastasis.
The IBs of tumour cell proliferation and necrosis will be developed respectively from FLT PET and ADC MRI respectively. Initial apoptosis plans focus on ICMT11 PET, possibly with other IBs introduced later. The project will be delivered using a portfolio of animal (WP2), human (WP3), image analysis (WP4) and regulatory (WP5) work. The project will be coordinated and the interdependent workpackages integrated in WP1. These WPs will deliver image acquisition and analysis protocols which are technically valid, standardised and suitable for multicentre use. We will evaluate reproducibility, effects of intervention, timing, dose-response, and imaging-histopathology correlation in animals and patients. The project is timely, and highly likely to deliver IBs which will markedly improve drug development, and benefit cancer patients in Europe and globally. The managing entity (EORTC) is already world-leading in the qualification of IBs, and the consortium includes in the academic and EFPIA partners some of the world's most productive and innovative physicians and scientists in cancer imaging.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
IMI-JU-02-2009
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)
Coordinator
1200 Bruxelles / Brussel
Belgium
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Participants (23)
151 85 Sodertaelje
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Participation ended
E20 1JQ LONDON
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M13 9PL Manchester
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48149 Muenster
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6525 XZ Nijmegen
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75654 PARIS
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6229 ET Maastricht
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1081 HV Amsterdam
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WC2R 2LS London
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2650 EDEGEM
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SW7 3RP London
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3015 GD Rotterdam
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SW7 2AZ London
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44815 Saint-Herblain
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8092 Zurich
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1831 Diegem
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RG21 4FA BASINGSTOKE
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WC1A 1DG LONDON
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64293 Darmstadt
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CT13 9NJ Sandwich
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4070 Basel
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94250 Gentilly
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CB2 1TN CAMBRIDGE
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