DIabetes REsearCh on patient sTratification

Project Information

DIRECT

Grant agreement ID: 115317

Project closed

Start date 1 February 2012

End date 31 July 2019

Funded under

• Specific Programme "Cooperation": Joint Technology Initiatives

Total cost € 46 484 127,00

EU contribution € 21 388 643,00

Coordinated by

SANOFI-AVENTIS DEUTSCHLAND GMBH
Germany

Objective

The overarching aims of the DIRECT consortium, consisting of 20 leading academic groups in diabetes and 5 EFPIA companies, are to identify biomarkers that address current bottlenecks in diabetes drug development and to develop a stratified medicines approach to treatment of type 2 diabetes with either existing or novel therapies.
There is heterogeneity in who develops diabetes, the rate at which their subsequent diabetes progresses, how they respond to diabetes therapy and who develops micro- and macrovascular complications. In the DIRECT consortium we propose to identify biomarkers to identify subtypes with rapid diabetes development and progression and altered response to diabetes treatments, and develop and use these biomarkers in clinical trials.
Two phenotyping work packages will focus on glycaemic deterioration and therapeutic response. For each, the DIRECT consortium brings considerable existing resource, which will be augmented by large-scale prospective cohort collection with intensive physiological and imaging phenotyping. Additional data will be added, such as existing studies on acute response to intravenous beta-cell secretagogues, and functional genomics on human islets, liver, muscle and adipose tissue, to maximise the power and utility of an innovative integrated biology approach. To enable computational multi-level integration across phenotypes and data types, a robust and secure data repository will be developed with strict data governance. As the ultimate aim of DIRECT is patient stratification, biomarkers arising from the discovery work will be used to design one or more prospective clinical trials. These will validate the biomarker(s) of interest, and establish utility in clinical practice and/or trial design and drug development. As a result, this consortium offers considerable potential to achieve major progress towards a personalized medicines approach to the treatment of type 2 diabetes.

Fields of science

• medical and health sciences › basic medicine › pharmacology and pharmacy › drug discovery
• natural sciences › biological sciences › genetics
• social sciences › sociology › governance
• medical and health sciences › clinical medicine › endocrinology › diabetes
• medical and health sciences › health sciences › personalized medicine

Programme(s)

• FP7-JTI - Specific Programme "Cooperation": Joint Technology Initiatives

Topic(s)

• IMI-JU-03-2010-06 - Development Of Personalized Medicine Approaches In Diabetes

Call for proposal

IMI-JU-03-2010
See other projects for this call

Funding Scheme

JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)

Coordinator

SANOFI-AVENTIS DEUTSCHLAND GMBH

• EU contribution: No data
• Address: BRUNINGSTRASSE 50 ; 65929 Frankfurt Am Main ; Germany
• Region: Hessen › Darmstadt › Frankfurt am Main, Kreisfreie Stadt
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Bernd Jablonka (Dr.)
• Principal investigator: Hartmut Ruetten (Dr.)
• Total cost: No data

Participants (25)

UNIVERSITY OF DUNDEE

United Kingdom

• EU contribution: € 1 805 896,00
• Address: Nethergate ; DD1 4HN Dundee
• Region: Scotland › Eastern Scotland › Angus and Dundee City
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: McLeod Alison-Carleton (Mrs.)
• Total cost: No data

UNIVERSITY OF BATH

United Kingdom

• EU contribution: € 215 444,00
• Address: CLAVERTON DOWN ; BA2 7AY Bath
• Region: South West (England) › Gloucestershire, Wiltshire and Bristol/Bath area › Bath and North East Somerset, North Somerset and South Gloucestershire
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Pete Hompstead (Mr.)
• Total cost: No data

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

• EU contribution: € 186 288,00
• Address: PIAZZALE ALDO MORO 7 ; 00185 Roma
• Region: Centro (IT) › Lazio › Roma
• Activity type: Research Organisations
• Administrative Contact: Michela Matteoli (Prof.)
• Total cost: No data

DANMARKS TEKNISKE UNIVERSITET

Denmark

• EU contribution: € 1 753 950,00
• Address: ANKER ENGELUNDS VEJ 101 ; 2800 Kongens Lyngby
• Region: Danmark › Hovedstaden › Københavns omegn
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Kristina Holdgaard-Sorensen (Ms.)
• Total cost: No data

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

• EU contribution: € 4 800,00
• Address: GESCHWISTER-SCHOLL-PLATZ ; 72074 Tuebingen
• Region: Baden-Württemberg › Tübingen › Tübingen, Landkreis
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Andreas Fritsche (Prof.)
• Total cost: No data

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

• EU contribution: € 1 817 759,00
• Address: INGOLSTADTER LANDSTRASSE 1 ; 85764 Neuherberg
• Region: Bayern › Oberbayern › München, Landkreis
• Activity type: Research Organisations
• Administrative Contact: Juergen Ertel (Dr.)
• Total cost: No data

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

Spain

• EU contribution: € 284 600,00
• Address: CALLE ROSSELLO 149 PUERTA BJS ; 08036 Barcelona
• Region: Este › Cataluña › Barcelona
• Activity type: Other
• Administrative Contact: JUAN M. ABOLAFIA (Dr.)
• Total cost: No data

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

• EU contribution: € 385 603,00
• Address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD ; SW7 2AZ LONDON
• Region: London › Inner London — West › Westminster
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Tanya Palalic (Ms.)
• Total cost: No data

KUNGLIGA TEKNISKA HOEGSKOLAN

Sweden

• EU contribution: € 2 097 994,00
• Address: BRINELLVAGEN 8 ; 100 44 Stockholm
• Region: Östra Sverige › Stockholm › Stockholms län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Åke Eriksson (Mr.)
• Total cost: No data

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

• EU contribution: € 1 416 593,00
• Address: RUE MICHEL ANGE 3 ; 75794 Paris
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Sandra Dupire (Mrs.)
• Total cost: No data

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

• EU contribution: € 543 444,00
• Address: ALBINUSDREEF 2 ; 2333 ZA Leiden
• Region: West-Nederland › Zuid-Holland › Agglomeratie Leiden en Bollenstreek
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Karin Wibier (-)
• Total cost: No data

KOBENHAVNS UNIVERSITET

Denmark

• EU contribution: € 1 093 889,00
• Address: NORREGADE 10 ; 1165 Kobenhavn
• Region: Danmark › Hovedstaden › Byen København
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Arnold Boon (-)
• Total cost: No data

ITA-SUOMEN YLIOPISTO

Finland

• EU contribution: € 1 635 413,00
• Address: YLIOPISTONRANTA 8 ; 70211 KUOPIO
• Region: Manner-Suomi › Pohjois- ja Itä-Suomi › Pohjois-Savo
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Tiina Reinikainen (Ms.)
• Total cost: No data

LUNDS UNIVERSITET

Sweden

• EU contribution: € 1 570 964,00
• Address: Paradisgatan 5c ; 22100 Lund
• Region: Södra Sverige › Sydsverige › Skåne län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Jacqueline Postma (Dr.)
• Total cost: No data

UNIVERSITY OF NEWCASTLE UPON TYNE

United Kingdom

• EU contribution: € 378 085,00
• Address: KINGS GATE ; NE1 7RU Newcastle Upon Tyne
• Region: North East (England) › Northumberland and Tyne and Wear › Tyneside
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Helen Gallon (Ms.)
• Total cost: No data

THE UNIVERSITY OF EXETER

United Kingdom

• EU contribution: € 1 734 738,00
• Address: THE QUEEN'S DRIVE NORTHCOTE HOUSE ; EX4 4QJ Exeter
• Region: South West (England) › Devon › Devon CC
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Gaynor Hughes (Ms.)
• Total cost: No data

UNIVERSITE DE GENEVE

Switzerland

• EU contribution: € 1 225 700,00
• Address: RUE DU GENERAL DUFOUR 24 ; 1211 Geneve
• Region: Schweiz/Suisse/Svizzera › Région lémanique › Genève
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Emmanouil Dermitzakis (Prof)
• Total cost: No data

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

• EU contribution: € 1 864 143,00
• Address: WELLINGTON SQUARE UNIVERSITY OFFICES ; OX1 2JD Oxford
• Region: South East (England) › Berkshire, Buckinghamshire and Oxfordshire › Oxfordshire
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Stephen Conway (Dr)
• Total cost: No data

UNIVERSITAET ULM

Germany

• EU contribution: € 100 000,00
• Address: HELMHOLTZSTRASSE 16 ; 89081 Ulm
• Region: Baden-Württemberg › Tübingen › Ulm, Stadtkreis
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Frank Gleixner (Mr.)
• Total cost: No data

STICHTING AMSTERDAM UMC

Netherlands

• EU contribution: € 1 072 269,00
• Address: DE BOELELAAN 1117 ; 1081 HV Amsterdam
• Region: West-Nederland › Noord-Holland › Groot-Amsterdam
• Activity type: Research Organisations
• Administrative Contact: Yvonne Koppelman (Dr.)
• Total cost: No data

NOVO NORDISK A/S

Denmark

• EU contribution: No data
• Address: NOVO ALLE 1 ; 2880 Bagsvaerd
• Region: Danmark › Hovedstaden › Københavns omegn
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Martin Ridderstrale (Dr.)
• Total cost: No data

ELI LILLY AND COMPANY LTD

United Kingdom

• EU contribution: No data
• Address: LILLY HOUSE BASINGVIEW ; RG21 4FA Basingstoke
• Region: South East (England) › Hampshire and Isle of Wight › North Hampshire
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Birgit Steckel-Hamann (Dr.)
• Total cost: No data

INSTITUT DE RECHERCHES INTERNATIONALES SERVIER

France

• EU contribution: No data
• Address: 22 ROUTE 128 ; 91190 GIF-SUR-YVETTE
• Region: Ile-de-France › Ile-de-France › Essonne
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Carole POHER (Ms.)
• Total cost: No data

CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE

France

• EU contribution: € 201 071,00
• Address: AVENUE OSCAR LAMBRET 2 ; 59037 Lille
• Region: Hauts-de-France › Nord-Pas de Calais › Nord
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Guillaume Tueux (Mr.)
• Total cost: No data

BOEHRINGER INGELHEIM INTERNATIONALGMBH

Germany

• EU contribution: No data
• Address: BINGER STRASSE ; 55218 Ingelheim
• Region: Rheinland-Pfalz › Rheinhessen-Pfalz › Mainz-Bingen
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Rolf Goeggel (Dr.)
• Total cost: No data