Objective The OrBiTo project will deliver novel methods and a framework for rational application of predictive biopharmaceutics tools for oral drug delivery. This will be achieved through novel propsective studies to define new methodlogies which will be validated using historical datasets from EFPIA partners. A combination of high quality in vitro or in silico characterizations of API and formulations will be integrated into physiologically based in silico models capturing the full complexity of oral drug absorption. This approach will drive model based pharmaceutical product development in accordance with visions of Quality by Design. Benefits include an accelerated formulation development process, particularly for challenging projects e.g. for low solubility molecules or modified-release formulations as well as allowing optimization of clinical product performance for patient benefit. In addition, it will significantly reduce the need for future animal experiments in this area and reduce the need for human bioequivalence studies for bridging between formulations within clinical programmes. The consortium is composed of world-leading scientists in a unique multidisciplinary collaboration where competences from nine academic partners, one regulatory agency, one non-profit research organisation and three SMEs are brought together with the twelve EFPIA partners giving an unparalleled opportunity to deliver transformational change in European industrial product development. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs Programme(s) FP7-JTI - Specific Programme "Cooperation": Joint Technology Initiatives Topic(s) IMI-JU-04-2011-04 - In Vivo Predictive Biopharmaceutics Tools For Oral Drug Delivery Call for proposal IMI-JU-04-2011 See other projects for this call Funding Scheme JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI) Coordinator ASTRAZENECA AB EU contribution No data Address Vastra Maelarhamnen 151 85 Sodertaelje Sweden See on map Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Principal investigator Bertil Abrahamsson (Senior Principle Scientist) Administrative Contact Eva Lindgren (Senior Director) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (26) Sort alphabetically Sort by EU Contribution Expand all Collapse all UPPSALA UNIVERSITET Sweden EU contribution € 2 470 300,00 Address VON KRAEMERS ALLE 4 751 05 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Higher or Secondary Education Establishments Administrative Contact Krister Halldin (PhD) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF MANCHESTER United Kingdom EU contribution € 528 000,00 Address OXFORD ROAD M13 9PL Manchester See on map Region North West (England) Greater Manchester Manchester Activity type Higher or Secondary Education Establishments Administrative Contact Liz Fay (Ms) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAET GREIFSWALD Germany EU contribution € 606 225,00 Address DOMSTRASSE 11 17489 Greifswald See on map Region Mecklenburg-Vorpommern Mecklenburg-Vorpommern Vorpommern-Greifswald Activity type Higher or Secondary Education Establishments Administrative Contact Diana Lode (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Greece EU contribution € 488 400,00 Address 6 CHRISTOU LADA STR 10561 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Higher or Secondary Education Establishments Administrative Contact Efstathia Kafentzi (Secretary of the Research Committee) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO Netherlands EU contribution € 438 000,00 Address ANNA VAN BUERENPLEIN 1 2595 DA Den Haag See on map Region West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Activity type Research Organisations Administrative Contact C.J.O.M. (Kees) Strien, van (Controller) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CERTARA UK LIMITED United Kingdom EU contribution € 438 000,00 Address ONE LONDON WALL 6TH FLOOR EC2Y 5EB London See on map Region London Inner London — West Camden and City of London Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Susan Burkhill (Miss) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LAKEMEDELSVERKET Sweden EU contribution No data Address DAG HAMMARSKJOLDS VAG 42 75103 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Joakim Brandberg (Head of Legal Affairs) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PION INC.(UK) LTD United Kingdom EU contribution € 402 000,00 Address RIVERSIDE FOREST ROW BUSINESS PARK RH18 5DW FOREST ROW See on map Region South East (England) Surrey, East and West Sussex East Sussex CC Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Brett Paul Hughes (Mr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JOHANNES GUTENBERG-UNIVERSITAT MAINZ Germany EU contribution € 784 800,00 Address SAARSTRASSE 21 55122 Mainz See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Julia Dore (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN Germany EU contribution € 468 600,00 Address THEODOR W ADORNO PLATZ 1 60323 Frankfurt Am Main See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Edmund Kostewicz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF STRATHCLYDE United Kingdom EU contribution € 546 292,00 Address Richmond Street 16 G1 1XQ Glasgow See on map Region Scotland West Central Scotland Glasgow City Activity type Higher or Secondary Education Establishments Administrative Contact Martin Gregory (Mr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KOBENHAVNS UNIVERSITET Denmark EU contribution € 785 400,00 Address NORREGADE 10 1165 Kobenhavn See on map Region Danmark Hovedstaden Byen København Activity type Higher or Secondary Education Establishments Administrative Contact Arly Christophersen (Economic consultant) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 1 019 375,00 Address OUDE MARKT 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Elke Lammertyn (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ABBVIE DEUTSCHLAND GMBH & CO KG Germany EU contribution No data Address MAINZER STR. 81 65205 Wiesbaden See on map Region Hessen Darmstadt Wiesbaden, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Frank-Christophe Lintz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BAYER AKTIENGESELLSCHAFT Germany EU contribution No data Address KAISER-WILHELM-ALLEE 1 51373 Leverkusen See on map Region Nordrhein-Westfalen Köln Leverkusen, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Petra Freitag (Finance Administrator) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BOEHRINGER INGELHEIM INTERNATIONALGMBH Germany EU contribution No data Address BINGER STRASSE 55218 Ingelheim See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Mainz-Bingen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Rolf Göggel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. United Kingdom EU contribution No data Address Great West Road 980 TW89GS Brentford See on map Region London Outer London — West and North West Hounslow and Richmond upon Thames Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Sally Miles (-) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JANSSEN PHARMACEUTICA NV Belgium EU contribution No data Address TURNHOUTSEWEG 30 2340 Beerse See on map Region Vlaams Gewest Prov. Antwerpen Arr. Turnhout Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Anneleen Stincke (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data H. LUNDBECK AS Denmark EU contribution No data Address OTTILIAVEJ 7-9 2500 Valby See on map Region Danmark Hovedstaden Byen København Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ejner Moltzen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MERCK SHARP & DOHME CORP United States EU contribution No data Address ONE MERCK DRIVE 08889 Whitehouse Station Nj See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Karen McGurk (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NOVARTIS PHARMA AG Switzerland EU contribution No data Address LICHTSTRASSE 35 4056 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Barbara Stolz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ORION OYJ Finland EU contribution No data Address ORIONINTIE 1 02200 Espoo See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ville Hassinen (N/A) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PFIZER LIMITED United Kingdom EU contribution No data Address RAMSGATE ROAD CT13 9NJ Sandwich See on map Region South East (England) Kent East Kent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Olga Krylova (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT France EU contribution No data Address 82 AVENUE RASPAIL 94250 GENTILLY See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patricia Zane (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Simulations Plus, Inc. United States EU contribution No data Address 10th Street West 93534 Lancaster See on map Administrative Contact John DiBella (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BRISTOL-MYERS SQUIBB COMPANY CORP United States EU contribution No data Address PARK AVENUE 345 10154 New York See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jonathan Brown (xx) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
