Objective
In response to the need to tackle increasingly complex medical research questions, a growing amount of human health data is being collected, either in routine Electronic Healthcare Record (EHR) databases, through research-driven cohort studies, in biobanks or related efforts. However, data sources are typically fragmented and contain information gaps which prevent their full exploitation. EMIF aims to address this by developing a common Information Framework that enables improved access to these data sources, enhancement through linkage of the different sources and collection of additional new information. EMIF will focus on two specific research objectives in order to guide the development of the Information Framework: identification and evaluation of biomarkers i) of the risk for metabolic complications in obesity; ii) of Alzheimer’s Disease onset in the preclinical and prodromal phase, which in both cases will identify high-risk individuals for future intervention trials. To achieve this, a variety of data sources ranging from small-scale information-rich disease cohorts for biomarker discovery to large EHR data for population characterisation and biomarker validation will be utilised. An extreme phenotype approach will utilise the subpopulations at the extremes of a particular trait distribution using large-scale metabolomics and proteomics for biomarker evaluation. The development of the Information Framework will involve addressing data standards, semantic interoperability as well as ethics, data privacy, legal issues and the development of an IT platform for multi data sources access. The Information Framework will be designed to support the current research objectives, but more generally studies using human health data. The project consortium is a partnership between Academia and EFPIA and comprises a large number of world-renown experts in data access and linkage and the Metabolic and AD therapeutic areas, with many being involved in other related projects
Fields of science
Call for proposal
IMI-JU-04-2011
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Coordinator
2340 Beerse
Belgium
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Participants (61)
3015 GD Rotterdam
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28006 Madrid
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WC1E 6BT London
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35127 Padova
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69117 Heidelberg
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59000 Lille
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3810-193 Aveiro
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LE1 7RH Leicester
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08002 Barcelona
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75012 Paris
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50141 Firenze
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3528AE Utrecht
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8200 Aarhus
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50141 Firenze
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28359 Bremen
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35138 Padova
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51005 Tartu
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M13 9PL Manchester
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4056 Basel
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9830 Sint-Martens-Latem
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405 30 Goeteborg
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17177 Stockholm
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W1B 1AL LONDON
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CB2 1TN Cambridge
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00014 Helsingin Yliopisto
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02150 Espoo
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70211 KUOPIO
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56126 Pisa
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75654 Paris
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45711 Dattien
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04109 Leipzig
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G12 8QQ Glasgow
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1165 Kobenhavn
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TW89GS Brentford
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CT13 9NJ Sandwich
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2880 Bagsvaerd
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4070 Basel
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92284 Courbevoie
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55218 Ingelheim
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1831 Diegem
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1070 Bruxelles / Brussel
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WC2R 2LS London
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1081 HV Amsterdam
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82256 FURSTENFELDBRUCK
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25125 Brescia
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75006 Paris
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80539 Munchen
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2000 Antwerpen
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91054 Erlangen
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6200 MD Maastricht
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1736 SENNINGERBERG
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KT113EP Cobham
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9052 ZWIJNAARDE - GENT
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74370 ARGONAY
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UB13HW Southall
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CB25 9TU Cambridge
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OX1 2JD Oxford
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64293 Darmstadt
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23562 Lubeck
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08007 Barcelona
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EX4 4QJ Exeter
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